NAV

Epitizide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Epitizide
DrugBank Accession Number
DB13989
Background

Epitizide is an agent, commonly found in combination triamterene, used to produce diuresis.

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 425.84
Monoisotopic: 424.9552316
Chemical Formula
C10H11ClF3N3O4S3
Synonyms
  • Epithiazide
  • Epitizide
  • Epitizidum
  • Eptizida
External IDs
  • P 2105
  • P-2105
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Integrate drug-drug
interactions in your software
AbacavirEpitizide may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Epitizide.
AceclofenacThe therapeutic efficacy of Epitizide can be decreased when used in combination with Aceclofenac.
AcemetacinThe therapeutic efficacy of Epitizide can be decreased when used in combination with Acemetacin.
AcetaminophenEpitizide may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy.
Food Interactions
Not Available

Categories

ATC Codes
C03EA03 — Epitizide and potassium-sparing agents
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
5B266B85J1
CAS number
1764-85-8
InChI Key
RINBGYCKMGDWPY-UHFFFAOYSA-N
InChI
InChI=1S/C10H11ClF3N3O4S3/c11-5-1-6-8(2-7(5)23(15,18)19)24(20,21)17-9(16-6)3-22-4-10(12,13)14/h1-2,9,16-17H,3-4H2,(H2,15,18,19)
IUPAC Name
6-chloro-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
SMILES
NS(=O)(=O)C1=CC2=C(NC(CSCC(F)(F)F)NS2(=O)=O)C=C1Cl

References

General References
Not Available
ChemSpider
14906
ChEBI
135688
ChEMBL
CHEMBL2104605
Wikipedia
Epitizide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.346 mg/mLALOGPS
logP1.22ALOGPS
logP0.88Chemaxon
logS-3.1ALOGPS
pKa (Strongest Acidic)9.05Chemaxon
pKa (Strongest Basic)-3.2Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area118.36 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity85.62 m3·mol-1Chemaxon
Polarizability35.67 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0000900000-9f07e1aacb4427f7e20a
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-0000900000-47e27a2bbb7cb0971539
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a6r-0004900000-fdae1b9bd283d75e763a
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-0019300000-15edb23a30a602e46bae
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-03fr-6594100000-1c0501d5a82c10ef1ed4
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9110000000-7a35e8724a62d29db9ce
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at February 16, 2018 20:23 / Updated at February 21, 2021 18:54