Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal... DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment of internal contamination by transuranics.
- Mechanism
- Curator reviewed · 1 reference
The calcium and zinc trisodium salts of DTPA achieve the therapeutical potential by exchanging calcium and zinc cations with transuranic radionuclides to form higher affinity complexes and then promote their elimination by glomerular filtration into the urine. DTPA as an acid acts in a very similar way by sequestering ions with its eight coordinate bond forming sites.
- Primary indication
- DTPA is widely used in industry and medicine.Curator reviewed · 3 structured indications
- Formula / weight
- C14H23N3O10 · 393.349 g/mol (avg)
- First approval
- United States, 1976
- Also known as
- Diethylene triamine pentaacetic acid · Diethylenetriamine pentaacetic acid · Diethylenetriaminepentaacetate · Diethylenetriaminepentaacetic acid · DTP-A
Resolves to
QPCDCPDFJACHGM-UHFFFAOYSA-NSMILESOC(=O)CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=OWhat you can answer from here — as of September 12, 2026
Which other approved drugs treat the same conditions as Pentetic acid, and which companies have late-stage candidates in those indications?
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