Englitazone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Englitazone
DrugBank Accession Number
DB14035
Background

Englitazone is a hypoglycemic agent.

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 353.44
Monoisotopic: 353.10856465
Chemical Formula
C20H19NO3S
Synonyms
  • Englitazone
External IDs
  • CP 68722

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcarboseThe risk or severity of hypoglycemia can be increased when Acarbose is combined with Englitazone.
AcebutololThe therapeutic efficacy of Englitazone can be increased when used in combination with Acebutolol.
AcetazolamideThe therapeutic efficacy of Englitazone can be increased when used in combination with Acetazolamide.
AcetohexamideThe risk or severity of hypoglycemia can be increased when Acetohexamide is combined with Englitazone.
Acetyl sulfisoxazoleThe therapeutic efficacy of Englitazone can be increased when used in combination with Acetyl sulfisoxazole.
Food Interactions
Not Available

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Product Ingredients
IngredientUNIICASInChI Key
Englitazone sodiumVA5755GIJ8109229-57-4JQWYNJRCVYGLMO-GPPXSFHXSA-M

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
ZQW5577C3O
CAS number
109229-58-5
InChI Key
MVDXXGIBARMXSA-PYUWXLGESA-N
InChI
InChI=1S/C20H19NO3S/c22-19-18(25-20(23)21-19)12-14-6-9-17-15(10-14)7-8-16(24-17)11-13-4-2-1-3-5-13/h1-6,9-10,16,18H,7-8,11-12H2,(H,21,22,23)/t16-,18?/m1/s1
IUPAC Name
5-{[(2R)-2-benzyl-3,4-dihydro-2H-1-benzopyran-6-yl]methyl}-1,3-thiazolidine-2,4-dione
SMILES
O=C1NC(=O)C(CC2=CC=C3O[C@@H](CC4=CC=CC=C4)CCC3=C2)S1

References

General References
Not Available
ChemSpider
5293364
ChEMBL
CHEMBL17669
Wikipedia
Englitazone

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00121 mg/mLALOGPS
logP3.72ALOGPS
logP4.35Chemaxon
logS-5.5ALOGPS
pKa (Strongest Acidic)6.61Chemaxon
pKa (Strongest Basic)-4.9Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area55.4 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity98.06 m3·mol-1Chemaxon
Polarizability37.55 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0019000000-346a9cdafc3841e86f8d
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0gx3-5197000000-7e22df17e76d8924fb00
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0092000000-fd09fa47cc9a915d6306
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9071000000-e5654e0c46dfc3af8afa
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001u-1391000000-9541635d5a1b72e954e4
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-000x-9071000000-91c584ad6bf155936f59
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at May 17, 2018 18:10 / Updated at February 21, 2021 18:54