Malacidin B, along with DB14051, is a member of a class of chemicals made by bacteria found in soil that can kill Gram-positive bacteria . Malacidins are 10-member macrocycle lipopeptides... Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis.
- Mechanism
- Curator reviewed
Malacidin B appears to bind Lipid II via a calcium dependent mechanism despite the absence of the typical Asp-X-Asp-Gly motif associate with calcium binding. The structure of Malacidin B includes a 3-hydroxy-aspartate residue while the "X" variable spacer residue is absent. It is unknown how these unique structural features may impact the drug's mechanism of action. The binding of Malacidin B to Lipid II prevents the incorporation of the subunit into the cell wall, disrupting synthesis and likely resulting in death of the bacterial cell. Malacidin B does not appear to form pores nor does it seem to integrate into the cell wall. While this mechanism is similar to that of DB00512, Malacidin B retains its activity against DB00512-resistant pathogens. Unlike other antibiotic agents, Malacidin B also retains its activity in the presence of pulmonary surfactants.
- Primary indication
- Malacidin B is being investigated for its antibiotic action and has potential for use as an antibacterial agent in the future.Curator reviewed
- Formula / weight
- C57H90N12O20 · 1263.411 g/mol (avg)
Resolves to
SMTCDPMWINUUKC-AVBBYWJWSA-NSMILESCCC(C)CC\C=C/C=C/C(=O)N[C@@H](C(C)C(O)=O)C(=O)N[C@H]1C(C)NC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](NC1=O)C(C)C)C(O)C(O)=O)C(C)C(O)=O)C(C)CWhat you can answer from here — as of April 02, 2025
Which companies are running trials of Malacidin B, in which indications and phases, and which of those programs are still active?
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