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Medronic acid

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
Medronic acid
DrugBank Accession Number
DB14078
Background

Not Available

Type
Small Molecule
Groups
Approved, Investigational
Structure
3D
Similar Structures
Weight
Average: 176.0023
Monoisotopic: 175.963960948
Chemical Formula
CH6O6P2
Synonyms
  • Acide medronique
  • Acido medronico
  • Acidum medronicum
  • Medronate
  • Medronic acid
  • methanebisphosphonic acid
  • methanediphosphonic acid
  • methanediylbis(phosphonic acid)
  • Methylene-1,1-bisphosphonic acid
  • Methylenediphosphonic acid
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Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination as diagnostic agentAltered osteogenesisCombination Product in combination with: Ascorbic acid (DB00126), Stannous fluoride (DB11092), Technetium Tc-99m (DB14227)••••••••••••••••••
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
MdpInjection, powder, lyophilized, for solution10 mg/1IntravenousMedi-Physics Inc. dba GE Healthcare1979-06-262009-06-01US flag
Technetium Tc 99m MedronateInjection, powder, for solution25 mg/1IntravenousJubilant DraxImage Inc., dba Jubilant Radiopharma2004-02-27Not applicableUS flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
73OS0QIN3O
CAS number
1984-15-2
InChI Key
MBKDYNNUVRNNRF-UHFFFAOYSA-N
InChI
InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)
IUPAC Name
(phosphonomethyl)phosphonic acid
SMILES
OP(O)(=O)CP(O)(O)=O

References

General References
  1. DailyMed: Kit for the Preparation of Technetium Tc 99m Medronate for Injection [Link]
  2. FDA Approved Products: DRAXIMAGE® MDP-25 (Kit for the Preparation of Technetium Tc 99m Medronate Injection) [Link]
KEGG Drug
D04887
ChemSpider
15308
BindingDB
50162816
RxNav
1314368
ChEBI
43945
ChEMBL
CHEMBL180570
ZINC
ZINC000008015016
PDBe Ligand
MDN
Wikipedia
Medronic_acid
PDB Entries
1huz / 3hxy / 5tlh / 5ysp / 6s83 / 7e4l

Clinical Trials

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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2Not Yet RecruitingTreatmentCastration-Resistant Prostate Carcinoma / Metastatic Malignant Neoplasm in the Bone / Stage IVB Prostate Cancer AJCC v81somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntravenous10 mg
Injection, powder, lyophilized, for solutionIntravenous10 mg/1
Injection, powder, for solutionIntravenous25 mg/1
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility16.0 mg/mLALOGPS
logP-0.97ALOGPS
logP-2.4Chemaxon
logS-1ALOGPS
pKa (Strongest Acidic)1.27Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count4Chemaxon
Polar Surface Area115.06 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity27.88 m3·mol-1Chemaxon
Polarizability11.22 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-3900000000-6dd15961d399aea4d6b1
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-0900000000-87a156425fa5fc5f45a5
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-004j-9300000000-dc815bb56dc856cbc43b
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-01t9-9000000000-3df6e4825072b74f45df
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-1900000000-9fa3fd2a43881b09b8c6
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-27cd16a3dcf75d49c743
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-130.8839611
predicted
DarkChem Lite v0.1.0
[M-H]-92.904465
predicted
DeepCCS 1.0 (2019)
[M+H]+96.570755
predicted
DeepCCS 1.0 (2019)
[M+Na]+105.085495
predicted
DeepCCS 1.0 (2019)

Drug created at June 17, 2018 17:04 / Updated at February 21, 2021 18:54