This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Tocopherylquinone
- DrugBank Accession Number
- DB14094
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental, Investigational
- Structure
Structure for Tocopherylquinone (DB14094)
- Weight
- Average: 446.7055
Monoisotopic: 446.375995466 - Chemical Formula
- C29H50O3
- Synonyms
- alpha-Tocopherol quinone
- alpha-Tocopherolquinone
- alpha-Tocopheroquinone
- alpha-Tocopherylquinone
- alpha-Tocoquinone
- ATQ
- Metarene
- Vitamin E quinone
- External IDs
- A-0001
- A0001
- EPIA-0001
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbaloparatide Abaloparatide may increase the hypotensive activities of Tocopherylquinone. Abciximab The risk or severity of bleeding can be increased when Abciximab is combined with Tocopherylquinone. Acebutolol Acebutolol may increase the hypotensive activities of Tocopherylquinone. Aceclofenac The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Tocopherylquinone. Acemetacin The risk or severity of bleeding and hemorrhage can be increased when Tocopherylquinone is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Tocopherylquinone. Acetylsalicylic acid Acetylsalicylic acid may increase the anticoagulant activities of Tocopherylquinone. Albutrepenonacog alfa The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Tocopherylquinone. Alclofenac The risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Tocopherylquinone. Aldesleukin The risk or severity of bleeding can be increased when Tocopherylquinone is combined with Aldesleukin. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Tocopherylquinone (30 [iU]/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + Doconexent (230 mg/1) + Ferrous bisglycinate (32 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin E (2 [iU]/1) + Zinc oxide (10 mg/1) Capsule, gelatin coated; Kit; Tablet Oral WOMENS CHOICE PHARMACEUTICALS LLC 2011-02-01 Not applicable US 
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- ZO763K43XR
- CAS number
- 7559-04-8
- InChI Key
- LTVDFSLWFKLJDQ-IEOSBIPESA-N
- InChI
- InChI=1S/C29H50O3/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8,32)19-17-26-25(7)27(30)23(5)24(6)28(26)31/h20-22,32H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
- IUPAC Name
- 2-[(3R,7R,11R)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione
- SMILES
- CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@@](C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 2015844
- BindingDB
- 50041386
- 1376149
- ChEMBL
- CHEMBL1223852
- ZINC
- ZINC000008214693
- PDBe Ligand
- VTQ
- PDB Entries
- 1olm
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Friedreich's Ataxia 1 2 Terminated Treatment Neuromuscular Disorders 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule, gelatin coated; kit; tablet Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000414 mg/mL ALOGPS logP 7.09 ALOGPS logP 9.03 Chemaxon logS -6 ALOGPS pKa (Strongest Acidic) 19.44 Chemaxon pKa (Strongest Basic) -0.86 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 54.37 Å2 Chemaxon Rotatable Bond Count 15 Chemaxon Refractivity 137.43 m3·mol-1 Chemaxon Polarizability 56.76 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at June 18, 2018 18:12 / Updated at July 11, 2020 03:43