Ceramide NP

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Ceramide NP
Accession Number
DB14111
Description

Ceramide NP is a lipid molecule included in a group of lipid molecules called ceramides. Ceramides are major lipid components in the stratum corneum of the human skin. Ceramide 3 consists of a phytosphingosine backbone N-acylated with a saturated fatty acid (stearic acid) 2. It is widely used as a moisturizer in various cosmetic and personal products. Together with ceramide 1, they synergistically improve the skin barrier function in humans 1,2.

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 581.967
Monoisotopic: 581.53830977
Chemical Formula
C36H71NO4
Synonyms
  • Cer(t18:0/18:1n-9)
  • Ceramide 3
  • Ceramide III
  • Ceramide IIIb
  • Cytomide IIIa
  • Cytomide IIIb
  • N-(9Z-octadecenoyl)-4-hydroxysphinganine
  • N-(9Z-octadecenoyl)phytosphingosine
  • N-octadecanoylphytosphingosine
  • N-oleoylphytosphingosine
  • N-oloeoyl-4-hydroxysphinganine

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Cellapy A RepairLotion0.05 1/200mLTopicalGm Holdings Co., Ltd2014-10-22Not applicableUS flag
Cellapy A Repair CreamCream0.1 1/100mLTopicalGm Holdings Co., Ltd2014-10-15Not applicableUS flag
JNH Ato-Care Super Barried ATO-SerumLiquid1.5 mg/50mLTopicalDaeduck Lab Co., Ltd.2012-08-24Not applicableUS flag
Sonatural Deep Moisture Cerafocus Enhance CeramideCream1.5 g/50mLTopicalSonatural Global Co.,ltd2017-03-022018-12-01US flag
Additional Data Available
  • Application Number
    Application Number
    Available for Purchase

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code
    Available for Purchase

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Energy Boosting TonerCeramide NP (0.01 g/100mL) + Adenosine (0.04 g/100mL) + Tremella fuciformis whole (0.1 g/100mL)LiquidTopicalAri&j Inc2017-07-05Not applicableUS flag
Moisture BoundCeramide NP (0.01 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Tremella fuciformis whole (0.1 g/100mL)CreamTopicalAri&j Inc2017-07-05Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Cellapy A RepairCeramide NP (0.05 1/200mL)LotionTopicalGm Holdings Co., Ltd2014-10-22Not applicableUS flag
Cellapy A Repair CreamCeramide NP (0.1 1/100mL)CreamTopicalGm Holdings Co., Ltd2014-10-15Not applicableUS flag
Energy Boosting TonerCeramide NP (0.01 g/100mL) + Adenosine (0.04 g/100mL) + Tremella fuciformis whole (0.1 g/100mL)LiquidTopicalAri&j Inc2017-07-05Not applicableUS flag
JNH Ato-Care Super Barried ATO-SerumCeramide NP (1.5 mg/50mL)LiquidTopicalDaeduck Lab Co., Ltd.2012-08-24Not applicableUS flag
Moisture BoundCeramide NP (0.01 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Tremella fuciformis whole (0.1 g/100mL)CreamTopicalAri&j Inc2017-07-05Not applicableUS flag
Sonatural Deep Moisture Cerafocus Enhance CeramideCeramide NP (1.5 g/50mL)CreamTopicalSonatural Global Co.,ltd2017-03-022018-12-01US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phytoceramides. These are n-acylated 4-hydroxysphinganine.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Sphingolipids
Sub Class
Ceramides
Direct Parent
Phytoceramides
Alternative Parents
N-acyl amines / Secondary carboxylic acid amides / Secondary alcohols / Polyols / Primary alcohols / Organopnictogen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Fatty acyl / Fatty amide / Hydrocarbon derivative / N-acyl-4-hydroxysphinganine / N-acyl-amine
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
phytoceramide (CHEBI:85204)

Chemical Identifiers

UNII
4370DF050B
CAS number
100403-19-8
InChI Key
ATGQXSBKTQANOH-UWVGARPKSA-N
InChI
InChI=1S/C36H71NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-35(40)37-33(32-38)36(41)34(39)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h17-18,33-34,36,38-39,41H,3-16,19-32H2,1-2H3,(H,37,40)/b18-17-/t33-,34+,36-/m0/s1
IUPAC Name
(9Z)-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadec-9-enamide
SMILES
CCCCCCCCCCCCCC[[email protected]@H](O)[[email protected]@H](O)[[email protected]](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC

References

General References
  1. Huang HC, Chang TM: Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. Int J Dermatol. 2008 Aug;47(8):812-9. doi: 10.1111/j.1365-4632.2008.03687.x. [PubMed:18717861]
  2. Choi SM, Lee BM: Safety and risk assessment of ceramide 3 in cosmetic products. Food Chem Toxicol. 2015 Oct;84:8-17. doi: 10.1016/j.fct.2015.07.012. Epub 2015 Jul 21. [PubMed:26206496]
  3. Kucharekova M, Schalkwijk J, Van De Kerkhof PC, Van De Valk PG: Effect of a lipid-rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction. Contact Dermatitis. 2002 Jun;46(6):331-8. [PubMed:12190621]
ChemSpider
29320046
ChEBI
85204
ZINC
ZINC000200105160

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LotionTopical0.05 1/200mL
CreamTopical0.1 1/100mL
LiquidTopical
LiquidTopical1.5 mg/50mL
CreamTopical
CreamTopical1.5 g/50mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility9.71e-05 mg/mLALOGPS
logP9.05ALOGPS
logP10.52ChemAxon
logS-6.8ALOGPS
pKa (Strongest Acidic)13.27ChemAxon
pKa (Strongest Basic)-1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area89.79 Å2ChemAxon
Rotatable Bond Count32ChemAxon
Refractivity176.49 m3·mol-1ChemAxon
Polarizability77.39 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on June 21, 2018 11:23 / Updated on June 12, 2020 10:53

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