Silodrate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Silodrate
DrugBank Accession Number
DB14116
Background

Not Available

Type
Small Molecule
Groups
Approved, Experimental
Structure
Weight
Average: 380.832
Monoisotopic: 379.8185655
Chemical Formula
Al2H2Mg2O12Si3
Synonyms
  • Magnesium aluminometasilicate
  • Silodrate
  • Simaldrate
External IDs
  • MP-1051

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatAcid indigestionCombination Product in combination with: Simethicone (DB09512), Magnesium hydroxide (DB09104)••• •••
Used in combination to treatFlatulenceCombination Product in combination with: Simethicone (DB09512), Magnesium hydroxide (DB09104)••• ••••••• •••••••••••
Used in combination to treatFlatulenceCombination Product in combination with: Simethicone (DB09512), Magnesium hydroxide (DB09104)••• ••••••••••••
Used in combination to treatFlatulenceCombination Product in combination with: Magnesium hydroxide (DB09104), Simethicone (DB09512)••• ••••••• •••••••
Used in combination to treatHeartburnCombination Product in combination with: Simethicone (DB09512), Magnesium hydroxide (DB09104)••• •••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
  • Take separate from meals. Take Inon Ace (dimethicone, magnesium hydroxide, silodrate) between meals,.

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Inon AceSilodrate (200 mg/1) + Dimethicone (20 mg/1) + Magnesium hydroxide (60 mg/1)TabletOralSato Pharmaceutical Co., Ltd.1995-11-01Not applicableUS flag
Inon AceSilodrate (900 mg/30mL) + Magnesium hydroxide (250 mg/30mL)SolutionOralSato Pharmaceutical Co., Ltd.2000-05-20Not applicableUS flag

Categories

Drug Categories
Not Available
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as post-transition metal silicates. These are inorganic compounds in which the largest oxoanion is silicate, and in which the heaviest atom not in an oxoanion is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal oxoanionic compounds
Sub Class
Post-transition metal silicates
Direct Parent
Post-transition metal silicates
Alternative Parents
Miscellaneous silicates / Post-transition metal salts / Metalloid salts / Inorganic salts / Inorganic oxides
Substituents
Inorganic metalloid salt / Inorganic oxide / Inorganic post-transition metal salt / Inorganic salt / Post-transition metal silicate / Silicate
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
9T3UU8T0QK
CAS number
12408-47-8
InChI Key
JAUGGEIKQIHSMF-UHFFFAOYSA-N
InChI
InChI=1S/2Al.2Mg.3O3Si.H2O.2O/c;;;;3*1-4(2)3;;;/h;;;;;;;1H2;;/q2*+3;2*+2;3*-2;;2*-2
IUPAC Name
dialuminium(3+) dimagnesium(2+) tris(oxosilanebis(olate)) hydrate dioxidandiide
SMILES
O.[O--].[O--].[Mg++].[Mg++].[Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O

References

General References
Not Available
ChemSpider
32699010
RxNav
236730

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionOral
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1.4Chemaxon
pKa (Strongest Acidic)2.7Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area63.19 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity4.33 m3·mol-1Chemaxon
Polarizability4.22 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 22, 2018 20:42 / Updated at September 28, 2021 21:54