Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigen
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Identification
- Generic Name
- Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigen
- DrugBank Accession Number
- DB14417
- Background
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen". This defence includes the production of humoral immunity through the development of antibodies (through memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy the virus as there are circulating antibodies that recognize that particular component of the virus that it was previously exposed to.
There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques. Live vaccines maintain their replicative ability.
- Type
- Biotech
- Groups
- Approved
- Biologic Classification
- Vaccines
Recombinant - Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Prophylaxis of Influenza a virus infection •••••••••••• ••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Flublok Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigen (45 ug/0.5mL) + Influenza A virus A/Michigan/45/2015 (H1N1) recombinant hemagglutinin antigen (45 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 recombinant hemagglutinin antigen (45 ug/0.5mL) Injection, solution Intramuscular Protein Sciences Corporation 2017-07-14 2018-06-30 US Flublok Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigen (45 ug/0.5mL) + Influenza A virus A/California/7/2009 (H1N1) recombinant hemagglutinin antigen (45 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 recombinant hemagglutinin antigen (45 ug/0.5mL) Injection, solution Intramuscular Protein Sciences Corporation 2016-08-01 2017-06-30 US Flublok Quadrivalent Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigen (45 ug/0.5mL) + Influenza A virus A/Michigan/45/2015 (H1N1) recombinant hemagglutinin antigen (45 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 recombinant hemagglutinin antigen (45 ug/0.5mL) + Influenza B virus B/Phuket/3073/2013 recombinant hemagglutinin antigen (45 ug/0.5mL) Injection, solution Intramuscular Protein Sciences Corporation 2017-07-14 2018-06-30 US
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2I1EOL437M
- CAS number
- Not Available
References
- General References
- Not Available
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Not Available Acute Myocardial Infarction (AMI) / Congestive Heart Failure (CHF) / Flu caused by Influenza / Lower Respiratory Tract Infection (LRTI) / Pneumonia / Stroke 1 somestatus stop reason just information to hide Not Available Completed Not Available Flu caused by Influenza 1 somestatus stop reason just information to hide 4 Active Not Recruiting Basic Science Flu caused by Influenza 1 somestatus stop reason just information to hide 4 Completed Basic Science Flu caused by Influenza 1 somestatus stop reason just information to hide 4 Completed Prevention Adverse Event Following Immunization / Birth Outcomes / Safety 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, solution Intramuscular - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at July 05, 2018 18:02 / Updated at June 12, 2020 16:53