This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Brand Names
- Phexxi, Prismasol
- Generic Name
- L-Lactic acid
- DrugBank Accession Number
- DB14475
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Experimental
- Structure
Structure for L-Lactic acid (DB14475)
- Weight
- Average: 90.0779
Monoisotopic: 90.031694058 - Chemical Formula
- C3H6O3
- Synonyms
- (+)-lactic acid
- (S)-(+)-lactic acid
- (S)-2-hydroxypropanoic acid
- (S)-2-hydroxypropionic acid
- (S)-lactic acid
- L-(+)-lactic acid
- L-(+)-α-hydroxypropionic acid
- L-Lactic acid
- L-Milchsäure
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Phexxi L-Lactic acid (90 mg/5g) + Citric acid monohydrate (50 mg/5g) + Potassium bitartrate (20 mg/5g) Gel Vaginal Evofem, Inc. 2020-08-01 Not applicable US 
Prismasol 2 L-Lactic acid (5.400 g / 1000 mL) + Calcium chloride (5.145 g / 1000 mL) + D-glucose (22.00 g / 1000 mL) + Magnesium chloride (2.033 g / 1000 mL) + Potassium chloride (0.157 g / 1000 mL) + Sodium bicarbonate (3.090 g / 1000 mL) + Sodium chloride (6.450 g / 1000 mL) Solution Intravenous Vantive Ulc 2006-02-21 Not applicable Canada 
Prismasol 4 L-Lactic acid (5.4 g / L) + Calcium chloride (5.145 g / L) + D-glucose (22 g / L) + Magnesium chloride (2.033 g / L) + Potassium chloride (0.314 g / L) + Sodium bicarbonate (3.09 g / L) + Sodium chloride (6.45 g / L) Solution Intravenous Vantive Ulc 2006-02-21 Not applicable Canada
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as alpha hydroxy acids and derivatives. These are organic compounds containing a carboxylic acid substituted with a hydroxyl group on the adjacent carbon.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Hydroxy acids and derivatives
- Sub Class
- Alpha hydroxy acids and derivatives
- Direct Parent
- Alpha hydroxy acids and derivatives
- Alternative Parents
- Secondary alcohols / Monocarboxylic acids and derivatives / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alcohol / Aliphatic acyclic compound / Alpha-hydroxy acid / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic oxide / Organic oxygen compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- 2-hydroxypropanoic acid (CHEBI:422)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- F9S9FFU82N
- CAS number
- 79-33-4
- InChI Key
- JVTAAEKCZFNVCJ-REOHCLBHSA-N
- InChI
- InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
- IUPAC Name
- (2S)-2-hydroxypropanoic acid
- SMILES
- C[C@H](O)C(O)=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000190
- KEGG Compound
- C00186
- ChemSpider
- 96860
- 2462499
- ChEBI
- 422
- ChEMBL
- CHEMBL330546
- ZINC
- ZINC000004658560
- PDBe Ligand
- 2OP
- PDB Entries
- 1tj0 / 1tj1 / 1vq4 / 1vq5 / 1vq7 / 1w9n / 2vk8 / 2voj / 2w11 / 2wnz … show 27 more
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data0 Recruiting Basic Science Bacterial Vaginosis (BV) / Vulvovaginal Candidiasis 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Vaginal Solution Intravenous - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US10568855 No 2020-02-25 2033-03-15 US US6706276 No 2004-03-16 2022-03-06 US US11337989 No 2013-03-15 2033-03-15 US US11439610 No 2013-03-15 2033-03-15 US US11992472 No 2013-03-15 2033-03-15 US
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 562.0 mg/mL ALOGPS logP -0.79 ALOGPS logP -0.47 Chemaxon logS 0.79 ALOGPS pKa (Strongest Acidic) 3.78 Chemaxon pKa (Strongest Basic) -3.7 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 57.53 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 18.84 m3·mol-1 Chemaxon Polarizability 8.06 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 108.4461215 predictedDarkChem Lite v0.1.0 [M-H]- 108.5550215 predictedDarkChem Lite v0.1.0 [M-H]- 108.5330215 predictedDarkChem Lite v0.1.0 [M-H]- 117.44805 predictedDeepCCS 1.0 (2019) [M+H]+ 109.2184215 predictedDarkChem Lite v0.1.0 [M+H]+ 110.9467215 predictedDarkChem Lite v0.1.0 [M+H]+ 109.0196215 predictedDarkChem Lite v0.1.0 [M+H]+ 120.247345 predictedDeepCCS 1.0 (2019) [M+Na]+ 108.8337215 predictedDarkChem Lite v0.1.0 [M+Na]+ 108.9939215 predictedDarkChem Lite v0.1.0 [M+Na]+ 108.8913215 predictedDarkChem Lite v0.1.0 [M+Na]+ 128.415 predictedDeepCCS 1.0 (2019)
Drug created at July 06, 2018 16:17 / Updated at February 21, 2021 18:54