Calcium ascorbate

Identification

Generic Name
Calcium ascorbate
DrugBank Accession Number
DB14483
Background

Not Available

Type
Small Molecule
Groups
Approved, Nutraceutical
Structure
Thumb
Weight
Average: 390.31
Monoisotopic: 390.0111168
Chemical Formula
C12H14CaO12
Synonyms
  • Ascorbic acid calcium salt
  • Calcium ascorbate
  • Calcium ascorbate anhydrous
  • Calcium diascorbate
  • L-ascorbic acid, calcium salt (2:1)

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AmphetamineThe serum concentration of Amphetamine can be decreased when it is combined with Calcium ascorbate.
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Calcium ascorbate.
BleomycinThe therapeutic efficacy of Bleomycin can be decreased when used in combination with Calcium ascorbate.
BortezomibThe therapeutic efficacy of Bortezomib can be decreased when used in combination with Calcium ascorbate.
ChlorpropamideCalcium ascorbate may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Conjugated estrogensThe serum concentration of Calcium ascorbate can be decreased when it is combined with Conjugated estrogens.
DeferoxamineThe risk or severity of Cardiovascular Impairment can be increased when Calcium ascorbate is combined with Deferoxamine.
DextroamphetamineThe serum concentration of Dextroamphetamine can be decreased when it is combined with Calcium ascorbate.
DienestrolThe serum concentration of Calcium ascorbate can be decreased when it is combined with Dienestrol.
DiethylpropionThe serum concentration of Diethylpropion can be decreased when it is combined with Calcium ascorbate.
Interactions
Identify potential medication risks
Easily compare up to 40 drugs with our drug interaction checker.
Get severity rating, description, and management advice.
Learn more
Food Interactions
No interactions found.

Products

Products2
Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Product Ingredients
IngredientUNIICASInChI Key
Calcium ascorbate dihydrate183E4W213W5743-28-2RGJHWLDSRIHFKY-FWCDDDAWSA-L
Active Moieties
NameKindUNIICASInChI Key
Ascorbic acidsaltPQ6CK8PD0R50-81-7CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Ascorbate C-500Capsule500 mgOralSeroyal International Inc.1998-12-312001-08-09Canada flag
Buffered Vitamin C 1000mgTablet1000 mgOralGeneral Nutrition Canada Inc.1997-11-262005-08-05Canada flag
Calcium Ascorbate 1000mgCapsule1000 mg / capOralNatural Factors Nutritional Products Ltd.1996-12-312007-08-07Canada flag
Calcium Ascorbate Crystals 1250mg/0.25tspPowder1.25 g / 1.25 mLOralSwiss Herbal Remedies Ltd.1987-12-312009-08-04Canada flag
Calcium Ascorbate Crystals Vitamin C 1gm/mlPowder1 g / mLOralVita Health Products Inc1991-12-312004-07-26Canada flag
Calcium Ascorbate FccPowder4.5 g / 5 mLOralAlbi Naturals1981-12-312009-07-15Canada flag
Calcium Ascorbate PwrPowder825 mg / gOralJamieson Laboratories Ltd1979-12-312000-09-08Canada flag
Calcium Ascorbate Pwr 1.3gm/1.25mlPowder1.3 g / 1.25 mLOralGahler Enterprises Ltd.1982-12-312007-08-07Canada flag
Calcium Ascorbate Tab 500mgTablet500 mg / tabOralAlbi Imports Ltd.1986-12-312001-07-27Canada flag
Chewable Vitamin C Tab 250mgTablet250 mg / tabOralSutra Health Systems Canada1986-12-311996-12-12Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
A/o-26 - CapletCalcium ascorbate (250 mg) + Beta carotene (7500 unit) + Calcium (75 mg) + Copper (1 mg) + DL-alpha tocopheryl acetate (100 unit) + Folic acid (.4 mg) + Manganese (2.5 mg) + Racemethionine (50 mg) + Selenium (100 mcg) + Zinc (7.5 mg)TabletOralEnviro Tech International Canada1996-12-191999-07-26Canada flag
Aces CapletCalcium ascorbate (350 mg) + Beta carotene (15000 unit) + Chromium (25 mcg) + Selenium (100 mcg) + Vitamin E (200 unit) + Zinc (25 mg)TabletOralNu Life Nutrition Ltd.1997-08-152005-03-15Canada flag
Aces TabCalcium ascorbate (350 mg) + Cholecalciferol (200 unit) + Chromium (25 mcg) + Selenium (100 mcg) + Vitamin A (5000 unit) + Vitamin E (200 unit) + Zinc (25 mg)TabletOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada flag
Acti-megascorb Crystals PwrCalcium ascorbate (2 g / 5 mL) + Calcium (260 mg / 5 mL)PowderOralActi Form Ltd.1991-12-312005-03-21Canada flag
Acti-MN + B1 + C CapletCalcium ascorbate (100 mg) + Manganese (30.0 mg) + Thiamine hydrochloride (20 mg)TabletOralActi Form Ltd.1991-12-312005-03-21Canada flag
Adrien Gagnon Formule A-C-E + SeleniumCalcium ascorbate (500 mg) + Beta carotene (10000 unit) + Selenium (50 mcg) + Vitamin E (200 unit)CapsuleOralSantÉ Naturelle (Ag) LtÉe2002-02-222007-08-03Canada flag
Am CapsCalcium ascorbate (30 mg) + Beta carotene (2500 unit) + Biotin (150 mcg) + Cholecalciferol (200 unit) + Cyanocobalamin (5 mcg) + Folic acid (0.20 mg) + Nicotinamide (10 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (0.85 mg) + Selenium (50 mcg) + Thiamine (0.75 mg) + Vitamin E (15 unit)CapsuleOralNew Vision Nutritionals CompanyNot applicableNot applicableCanada flag
Astral C TabCalcium ascorbate (500 mg) + Calcium (65 mg)TabletOralAlbi Naturals1994-12-312008-07-17Canada flag
B.E.T. ComplexCalcium ascorbate (75 mg) + Beta carotene (1250 unit) + Chromium (400 mcg) + Cyanocobalamin (100 mcg) + Folic acid (0.2 mg) + Iodine (0.15 mg) + Magnesium (200 mg) + Manganese (5 mg) + Nicotinamide (35 mg) + Sodium metavanadate (75 mcg) + Ubidecarenone (10 mg) + Vitamin A palmitate (1250 unit) + alpha-Tocopherol succinate (50 unit)TabletOralAbundance Naturally Ltd2000-12-062004-06-30Canada flag
Body RoxCalcium ascorbate (167.0 mg) + Beta carotene (3000.0 unit) + Biotin (100.0 mcg) + Calcium (75.0 mg) + Cholecalciferol (133.0 unit) + Choline bitartrate (15.0 mg) + Chromium (50.0 mcg) + Copper (0.33 mg) + Cyanocobalamin (20.0 mcg) + Folic acid (0.267 mg) + Inositol (10.0 mg) + Magnesium (37.5 mg) + Manganese (1.0 mg) + Molybdenum (15.0 mcg) + Niacin (1.66 mg) + Nicotinamide (3.3 mg) + Calcium pantothenate (10.0 mg) + Potassium Iodide (0.05 mg) + Pyridoxine hydrochloride (3.0 mg) + Riboflavin (3.0 mg) + Selenium (40.0 mcg) + Silicon (1.0 mg) + Thiamine hydrochloride (3.0 mg) + Vanadium (10.0 mcg) + Zinc (4.0 mg) + alpha-Tocopherol succinate (66.7 unit)TabletOralUsana Health Sciences, Inc.2003-09-022008-06-27Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Cavan OneCalcium ascorbate dihydrate (25 mg/1) + Calcium (150 mg/1) + Cholecalciferol (170 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (260 mg/1) + Ferrous asparto glycinate (7 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Iron (20 mg/1) + Linoleic acid (30 mg/1) + Pyridoxine hydrochloride (25 mg/1) + alpha-Linolenic acid (30 mg/1)Capsule, gelatin coatedOralSeton Pharmaceuticals2009-10-302011-11-27US flag
Ferrex 150 Forte PlusCalcium ascorbate dihydrate (60 mg/1) + Calcium threonate (0.8 mg/1) + Cyanocobalamin (25 ug/1) + Folic acid (1 mg/1) + Iron (150 mg/1) + Succinic acid (50 mg/1)CapsuleOralBreckenridge Pharmaceutical, Inc.2008-08-012012-09-30US flag
Folcaps Care OneCalcium ascorbate dihydrate (24 mg/1) + Biotin (300 mg/1) + Calcium carbonate (100 mg/1) + Calcium threonate (1 mg/1) + Cholecalciferol (800 [iU]/1) + Doconexent (350 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (100 mg/1) + Iodine (150 ug/1) + Iron (27 mg/1) + Magnesium (50 mg/1) + Nicotinamide (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.5 mg/1) + Zinc (5 mg/1) + alpha-Linolenic acid (50 mg/1) + alpha-Tocopherol acetate (15 [iU]/1)Capsule, gelatin coatedOralMayne Pharma2009-05-012016-12-31US flag
Folcaps Omega-3Calcium ascorbate dihydrate (24 mg/1) + Calcium (150 mg/1) + Calcium threonate (1 mg/1) + Cholecalciferol (170 [iU]/1) + Doconexent (260 mg/1) + Ferrous asparto glycinate (7 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Iron (20 mg/1) + Pyridoxine hydrochloride (25 mg/1) + alpha-Linolenic acid (30 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)Capsule, gelatin coatedOralMayne Pharma2011-01-032016-12-31US flag
Nestabs ONECalcium ascorbate dihydrate (18 mg/1) + Cholecalciferol (6.25 ug/1) + Cyanocobalamin (15 ug/1) + Doconexent (225 mg/1) + Folic acid (1 mg/1) + Iron (38 mg/1) + Magnesium oxide (15 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Tocopherol (10 mg/1) + Zinc oxide (1 mg/1)Capsule, gelatin coatedOralWomens Choice Pharmaceuticals, Llc2017-07-20Not applicableUS flag
PrimaCareCalcium ascorbate dihydrate (25 mg/1) + Biotin (1 mg/1) + Calcium carbonate (100 mg/1) + Cholecalciferol (1000 [iU]/1) + Folic acid (1 mg/1) + Linoleic acid (50 mg/1) + Magnesium oxide (50 mg/1) + Nicotinamide (10 mg/1) + Omega-3 fatty acids (420 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine (50 mg/1) + Riboflavin (1.5 mg/1) + Zinc (15 mg/1) + alpha-Tocopherol acetate (15 [iU]/1)PillOralAvion Pharmaceuticals, Llc2017-01-23Not applicableUS flag
Se-Care ChewableCalcium ascorbate dihydrate (50 mg/1) + Calcium carbonate (250 mg/1) + Calcium threonate (50 mg/1) + Cholecalciferol (6 ug/1) + Cupric oxide (2 mg/1) + DL-alpha tocopheryl acetate (3.5 [iU]/1) + Ferrous fumarate (40 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Pyridoxine hydrochloride (2 mg/1) + Zinc oxide (15 mg/1)Tablet, chewableOralSeton Pharmaceuticals2009-05-012011-08-31US flag
Se-Care ConceiveCalcium ascorbate dihydrate (30 mg/1) + Calcium carbonate (200 mg/1) + Calcium threonate (30 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (30 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (100 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3.4 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (15 mg/1)Tablet, film coatedOralSeton Pharmaceuticals2009-05-052011-04-15US flag
Se-Natal 19 ChewableCalcium ascorbate dihydrate (100 mg/1) + Beta carotene (1000 [iU]/1) + Calcium carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (29 mg/1) + Folic acid (1 mg/1) + Nicotinamide (15 mg/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (20 mg/1)Tablet, chewableOralSeton Pharmaceuticals2009-07-01Not applicableUS flag
Se-Vate 21/7Calcium ascorbate dihydrate (60 mg/1) + Ascorbic acid (140 mg/1) + Calcium threonate (0.8 mg/1) + Cyanocobalamin (10 ug/1) + Ferrous asparto glycinate (70 mg/1) + Ferrous fumarate (81 mg/1) + Folic acid (1 mg/1) + Succinic acid (150 mg/1)KitOralSeton Pharmaceuticals2009-05-122011-05-30US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
J96U0ZD4Y6
CAS number
5743-27-1
InChI Key
BLORRZQTHNGFTI-ZZMNMWMASA-L
InChI
InChI=1S/2C6H8O6.Ca/c2*7-1-2(8)5-3(9)4(10)6(11)12-5;/h2*2,5,7-10H,1H2;/q;;+2/p-2/t2*2-,5+;/m00./s1
IUPAC Name
calcium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate)
SMILES
[Ca++].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

References

General References
Not Available
ChemSpider
22900989
ChEMBL
CHEMBL2146095
Wikipedia
Calcium_ascorbate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
TabletOral166.7 mg / tab
TabletOral1000 mg
CapsuleOral1000 mg / cap
PowderOral1.25 g / 1.25 mL
PowderOral1 g / mL
PowderOral4.5 g / 5 mL
PowderOral825 mg / g
PowderOral1.3 g / 1.25 mL
Capsule, gelatin coatedOral
TabletOral250 mg / tab
Tablet, coatedOral
Tablet, extended releaseOral
Powder, for solutionOral
TabletOral500 mg / tab
CapsuleOral
TabletOral
GelOral
CapsuleOral500 mg / cap
Tablet, effervescentOral
TabletOral
Tablet, film coated
Powder
CapsuleOral660 mg / cap
CapsuleOral500 mg
PowderOral1000 mg / 1.25 g
Capsule, liquid filledOral
PillOral
Tablet, chewableOral
Tablet, film coatedOral
KitOral
CapsuleOral200 mg / cap
EmulsionTopical
LiquidOral
TabletOral1 g
TabletOral500 mg
PowderOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility16.0 mg/mLALOGPS
logP-1.6ALOGPS
logP-1.9ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)4.36ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area110.05 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity47.58 m3·mol-1ChemAxon
Polarizability14.48 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on July 06, 2018 22:11 / Updated on October 22, 2021 23:18