This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Chloramine-T is a chlorinated disinfectant of the genitals and injured skin.

Generic Name
Tosylchloramide
Commonly known or available as Chloramine-T
DrugBank Accession Number
DB14708
Background

Tosylchloramide, also known as chloramine-T, is a chlorinated and deprotonated sulfonamide used as a mild disinfectant. It is not stable in the water dissolved form.

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 205.66
Monoisotopic: 204.9964274
Chemical Formula
C7H8ClNO2S
Synonyms
  • N-chloro-p-toluenesulfonamide
  • N-chlorotoluene-p-sulfonamide

Pharmacology

Indication

Not Available

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
BenzylpenicillinTosylchloramide may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Insulin aspartThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin aspart.
Insulin beefThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin beef.
Insulin degludecThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin degludec.
Insulin detemirThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin detemir.
Insulin glargineThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin glargine.
Insulin glulisineThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin glulisine.
Insulin humanThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin human.
Insulin lisproThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin lispro.
Insulin porkThe risk or severity of hypoglycemia can be increased when Tosylchloramide is combined with Insulin pork.
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Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Chloramine-T328AS34YM6127-65-1VDQQXEISLMTGAB-UHFFFAOYSA-N
Chloramine-T trihydrate4IU6VSV0EI7080-50-4NZYOAGBNMCVQIV-UHFFFAOYSA-N
International/Other Brands
Chloramin T / Chloraseptin / Chlorazol / Clorina / Disifin / Halamid / Minachlor / Trichlorol

Categories

ATC Codes
D08AX04 — Tosylchloramide sodium
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
UF17KA8AC5
CAS number
144-86-5
InChI Key
NXTVQNIVUKXOIL-UHFFFAOYSA-N
InChI
InChI=1S/C7H8ClNO2S/c1-6-2-4-7(5-3-6)12(10,11)9-8/h2-5,9H,1H3
IUPAC Name
N-chloro-4-methylbenzene-1-sulfonamide
SMILES
CC1=CC=C(C=C1)S(=O)(=O)NCl

References

General References
  1. AIFA Product Information: STERIDROLO (chloramine) powder [Link]
ChemSpider
29119
ChEBI
53782
ChEMBL
CHEMBL1625750
ZINC
ZINC000008576333
Wikipedia
Chloramine-T

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Powder, for solutionTopical2.5 g
Powder, for solutionTopical5 g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.388 mg/mLALOGPS
logP-1.6ALOGPS
logP1.85ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)4.89ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.17 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity48.59 m3·mol-1ChemAxon
Polarizability19.31 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at September 30, 2018 19:47 / Updated at August 09, 2022 08:59