This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Narlaprevir
- DrugBank Accession Number
- DB14760
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Narlaprevir (DB14760)
- Weight
- Average: 707.97
Monoisotopic: 707.429170498 - Chemical Formula
- C36H61N5O7S
- Synonyms
- Narlaprevir
- External IDs
- SCH 900518
- SCH-900518
- SCH900518
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2857LA2O07
- CAS number
- 865466-24-6
- InChI Key
- RICZEKWVNZFTNZ-IOBYQIKSSA-N
- InChI
- InChI=1S/C36H61N5O7S/c1-10-11-15-24(27(42)30(44)37-22-16-17-22)38-29(43)26-25-23(35(25,8)9)20-41(26)31(45)28(33(2,3)4)39-32(46)40-36(18-13-12-14-19-36)21-49(47,48)34(5,6)7/h22-26,28H,10-21H2,1-9H3,(H,37,44)(H,38,43)(H2,39,40,46)/t23-,24?,25-,26?,28?/m0/s1
- IUPAC Name
- N-cyclopropyl-3-{[(1R,5S)-3-{3,3-dimethyl-2-[({1-[(2-methylpropane-2-sulfonyl)methyl]cyclohexyl}carbamoyl)amino]butanoyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-2-oxoheptanamide
- SMILES
- CCCCC(NC(=O)C1[C@@H]2[C@H](CN1C(=O)C(NC(=O)NC1(CS(=O)(=O)C(C)(C)C)CCCCC1)C(C)(C)C)C2(C)C)C(=O)C(=O)NC1CC1
References
- General References
- Not Available
- External Links
- Wikipedia
- Narlaprevir
Clinical Trials
- Clinical Trials
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Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data3 Completed Treatment Hepatitis C Virus (HCV) Infection 1 somestatus stop reason just information to hide 2 Completed Treatment Chronic Hepatitis C Genotype 1 1 somestatus stop reason just information to hide 2 Completed Treatment Chronic hepatitis C genotype 1b 1 somestatus stop reason just information to hide 2 Completed Treatment Chronic Hepatitis C Virus (HCV) Infection 1 somestatus stop reason just information to hide 2, 3 Terminated Other Chronic Hepatitis C Virus (HCV) Infection / Hepacivirus 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00964 mg/mL ALOGPS logP 3.44 ALOGPS logP 3.5 Chemaxon logS -4.9 ALOGPS pKa (Strongest Acidic) 12.32 Chemaxon pKa (Strongest Basic) -0.41 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 170.85 Å2 Chemaxon Rotatable Bond Count 15 Chemaxon Refractivity 186.29 m3·mol-1 Chemaxon Polarizability 76.76 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at April 23, 2019 22:10 / Updated at February 21, 2021 18:54