This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Cycloguanil
- DrugBank Accession Number
- DB14763
- Background
Cycloguanil is the active metabolite of proguanil.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Cycloguanil (DB14763)
- Weight
- Average: 251.715
Monoisotopic: 251.09377318 - Chemical Formula
- C11H14ClN5
- Synonyms
- CGT
- Chlorguanide triazine
- Cycloguanilum
- Cycloguanyl
- External IDs
- BN-24-10
- BN2410
- WR 5473
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The therapeutic efficacy of Cycloguanil can be increased when used in combination with Acetazolamide. Acetophenazine The risk or severity of QTc prolongation can be increased when Cycloguanil is combined with Acetophenazine. Alimemazine The risk or severity of QTc prolongation can be increased when Cycloguanil is combined with Alimemazine. Artemether The risk or severity of QTc prolongation can be increased when Cycloguanil is combined with Artemether. Articaine The risk or severity of methemoglobinemia can be increased when Cycloguanil is combined with Articaine. Benzocaine The risk or severity of methemoglobinemia can be increased when Cycloguanil is combined with Benzocaine. Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Cycloguanil is combined with Benzyl alcohol. Bupivacaine The risk or severity of methemoglobinemia can be increased when Cycloguanil is combined with Bupivacaine. Butacaine The risk or severity of methemoglobinemia can be increased when Cycloguanil is combined with Butacaine. Butamben The risk or severity of methemoglobinemia can be increased when Cycloguanil is combined with Butamben. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Cycloguanil embonate TCO0SY4N3D 609-78-9 LUNRMKZYOGNOTR-UHFFFAOYSA-N
Categories
- ATC Codes
- P01BB02 — Cycloguanil embonate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as aminotriazines. These are organic compounds containing an amino group attached to a triazine ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Triazines
- Sub Class
- Aminotriazines
- Direct Parent
- Aminotriazines
- Alternative Parents
- Chlorobenzenes / Aryl chlorides / 1,3,5-triazines / Guanidines / Propargyl-type 1,3-dipolar organic compounds / Carboximidamides / Azacyclic compounds / Organopnictogen compounds / Organochlorides / Imines show 1 more
- Substituents
- 1,3,5-triazine / Aminotriazine / Aromatic heteromonocyclic compound / Aryl chloride / Aryl halide / Azacycle / Benzenoid / Carboximidamide / Chlorobenzene / Guanidine show 11 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 26RM326WVN
- CAS number
- 516-21-2
- InChI Key
- QMNFFXRFOJIOKZ-UHFFFAOYSA-N
- InChI
- InChI=1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16)
- IUPAC Name
- 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
- SMILES
- CC1(C)N=C(N)N=C(N)N1C1=CC=C(Cl)C=C1
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0060974
- ChemSpider
- 8697
- BindingDB
- 18792
- ChEBI
- 135029
- ChEMBL
- CHEMBL747
- ZINC
- ZINC000000001233
- PDBe Ligand
- 1CY
- Wikipedia
- Cycloguanil
- PDB Entries
- 3irm / 3irn / 3um6 / 3um8 / 4kne / 6hnc / 6nnh
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.246 mg/mL ALOGPS logP 1.06 ALOGPS logP 1.7 Chemaxon logS -3 ALOGPS pKa (Strongest Acidic) 16.13 Chemaxon pKa (Strongest Basic) 8.18 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 80 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 68.84 m3·mol-1 Chemaxon Polarizability 25.51 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Drug created at May 01, 2019 15:47 / Updated at June 12, 2020 16:53