Cycloguanil

DB14763ApprovedSmall molecule

Cycloguanil is the active metabolite of proguanil.

Mechanism: Pharmacologically active on Bifunctional dihydrofolate reductase-thymidylate synthase
Curator reviewed
Formula / weight: C₁₁H₁₄ClN₅ · 251.715 g/mol (avg)
Code names: BN-24-10 · WR 5473

Resolves to

Compound

Clinical / RWD

Structure

InChIKeyQMNFFXRFOJIOKZ-UHFFFAOYSA-NSMILESCC1(C)N=C(N)N=C(N)N1C1=CC=C(Cl)C=C1

Targets

What you can answer from here — as of September 16, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

77Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 10 drug categories

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Cycloguanil, and which of those have an active Phase 3 trial?

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