LGH-447

DB14943InvestigationalSmall molecule

LGH-447 is under investigation in clinical trial NCT02160951 (Dose Escalation Study of LGH447 in Japanese Patients With Relapsed and/or Refractory Hematologic Malignancies).

Formula / weight: C₂₄H₂₃F₃N₄O · 440.47 g/mol (avg)
Code names: LGH-447

Resolves to

Compound

UNII9TG5O4V25HCAS1210608-43-7ChEMBLCHEMBL3651966

Structure

InChIKeyVRQXRVAKPDCRCI-ZNMIVQPWSA-NSMILESC[C@@H]1C[C@H](N)C[C@@H](C1)C1=C(NC(=O)C2=NC(=C(F)C=C2)C2=C(F)C=CC=C2F)C=NC=C1

Targets

Q9P1W9PIM2

What you can answer from here — as of April 23, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with LGH-447, and which of those have an active Phase 3 trial?

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