This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Padsevonil
DrugBank Accession Number
DB14977
Background

Padsevonil is under investigation in clinical trial NCT03695094 (A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 432.79
Monoisotopic: 432.0446154
Chemical Formula
C14H14ClF5N4O2S
Synonyms
  • Padsevonil

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as n-substituted imidazoles. These are heterocyclic compounds containing an imidazole ring substituted at position 1.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Azoles
Sub Class
Imidazoles
Direct Parent
N-substituted imidazoles
Alternative Parents
Pyrrolidine-2-ones / N-alkylpyrrolidines / Thiadiazoles / Tertiary carboxylic acid amides / Heteroaromatic compounds / Lactams / Azacyclic compounds / Dialkyl ethers / Organofluorides / Organonitrogen compounds
show 7 more
Substituents
2-pyrrolidone / Alkyl chloride / Alkyl fluoride / Alkyl halide / Aromatic heteropolycyclic compound / Azacycle / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Dialkyl ether
show 19 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
0R1HN52K0N
CAS number
1294000-61-5
InChI Key
DCXFIOLWWRXEQH-SSDOTTSWSA-N
InChI
InChI=1S/C14H14ClF5N4O2S/c1-26-6-9-22-24-8(11(14(18,19)20)21-12(24)27-9)5-23-4-7(2-10(23)25)3-13(15,16)17/h7H,2-6H2,1H3/t7-/m1/s1
IUPAC Name
(4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one
SMILES
COCC1=NN2C(CN3C[C@@H](CC(F)(F)Cl)CC3=O)=C(N=C2S1)C(F)(F)F

References

General References
Not Available
ChemSpider
58828036

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedTreatmentDrug-resistant Epilepsy / Partial-Onset Seizures1
2CompletedTreatmentDrug-resistant Epilepsy / Partial-Onset Seizures1
2TerminatedTreatmentDrug-resistant Epilepsy / Partial-Onset Seizures1
1CompletedBasic ScienceAdult Study Participants / Elderly Study Participants1
1CompletedBasic ScienceEpilepsies1
1CompletedBasic ScienceHealthy Japanese Participants1
1CompletedBasic SciencePharmacokinetics1
1TerminatedBasic ScienceHealthy Female Participants1
1TerminatedBasic ScienceHealthy Study Participants1
1TerminatedBasic ScienceHealthy Study Participants / Impaired Hepatic Function1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0147 mg/mLALOGPS
logP2.68ALOGPS
logP2.52ChemAxon
logS-4.5ALOGPS
pKa (Strongest Basic)0.19ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area59.73 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity108.38 m3·mol-1ChemAxon
Polarizability36.25 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:39 / Updated at February 21, 2021 18:55