This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Flortaucipir
- DrugBank Accession Number
- DB15033
- Background
Flortaucipir is under investigation in clinical trial NCT03507257 (Longitudinal Early-onset Alzheimer's Disease Study Protocol).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Flortaucipir (DB15033)
- Weight
- Average: 263.275
Monoisotopic: 263.085875497 - Chemical Formula
- C16H10FN3
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- J09QS3Z3WB
- CAS number
- 1415379-56-4
- InChI Key
- GETAAWDSFUCLBS-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H
- IUPAC Name
- 2-fluoro-5-{5H-pyrido[4,3-b]indol-7-yl}pyridine
- SMILES
- FC1=CC=C(C=N1)C1=CC=C2C(NC3=C2C=NC=C3)=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 32699920
- 2571858
- ChEMBL
- CHEMBL3546271
- ZINC
- ZINC000148048492
- PDBe Ligand
- S9C
- PDB Entries
- 8byn
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Active Not Recruiting Diagnostic Alzheimer's Disease (AD) 1 4 Enrolling by Invitation Diagnostic Dementia With Lewy Body Disease 1 2 Completed Diagnostic Alzheimer's Disease (AD) / Cognitive Deficits 1 1 Enrolling by Invitation Basic Science Concussion, Brain 1 Not Available Recruiting Not Available Alzheimer's Disease (AD) 1 Not Available Recruiting Not Available Depression / Drive 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0111 mg/mL ALOGPS logP 3.52 ALOGPS logP 2.84 Chemaxon logS -4.4 ALOGPS pKa (Strongest Acidic) 13.03 Chemaxon pKa (Strongest Basic) 8.13 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 41.57 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 75.53 m3·mol-1 Chemaxon Polarizability 27.23 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at May 20, 2019 14:44 / Updated at June 12, 2020 16:53