Flortaucipir

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Flortaucipir
DrugBank Accession Number
DB15033
Background

Flortaucipir is under investigation in clinical trial NCT03507257 (Longitudinal Early-onset Alzheimer's Disease Study Protocol).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 263.275
Monoisotopic: 263.085875497
Chemical Formula
C16H10FN3
Synonyms
Not Available

Pharmacology

Indication

Not Available

Reduce drug development failure rates
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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
J09QS3Z3WB
CAS number
1415379-56-4
InChI Key
GETAAWDSFUCLBS-UHFFFAOYSA-N
InChI
InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H
IUPAC Name
2-fluoro-5-{5H-pyrido[4,3-b]indol-7-yl}pyridine
SMILES
FC1=CC=C(C=N1)C1=CC=C2C(NC3=C2C=NC=C3)=C1

References

General References
Not Available
ChemSpider
32699920
RxNav
2571858
ChEMBL
CHEMBL3546271
ZINC
ZINC000148048492
PDBe Ligand
S9C
PDB Entries
8byn

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Enrolling by InvitationDiagnosticDementia With Lewy Body Disease1
4RecruitingDiagnosticAlzheimer's Disease (AD)1
2CompletedDiagnosticAlzheimer's Disease (AD) / Cognitive Deficits1
1Enrolling by InvitationBasic ScienceConcussion, Brain1
Not AvailableRecruitingNot AvailableAlzheimer's Disease (AD)1
Not AvailableRecruitingNot AvailableDepression / Drive1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0111 mg/mLALOGPS
logP3.52ALOGPS
logP2.84Chemaxon
logS-4.4ALOGPS
pKa (Strongest Acidic)13.03Chemaxon
pKa (Strongest Basic)8.13Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area41.57 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity75.53 m3·mol-1Chemaxon
Polarizability27.23 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:44 / Updated at June 12, 2020 16:53