ABT-639

DB15055InvestigationalSmall molecule

ABT-639 is under investigation in clinical trial NCT01345045 (A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain).

Mechanism: Pharmacologically active on Voltage-dependent T-type calcium channel subunit alpha-1H
Curator reviewed
Formula / weight: C₂₀H₂₀ClF₂N₃O₃S · 455.9 g/mol (avg)
Code names: ABT-639

Resolves to

Compound

UNII0G7D0CQ88ICAS1235560-28-7ChEMBLCHEMBL3590674

Structure

InChIKeyAGPIHNZOZNKRGT-CYBMUJFWSA-NSMILESFC1=CC=CC=C1NS(=O)(=O)C1=C(F)C=C(Cl)C(=C1)C(=O)N1CCN2CCC[C@@H]2C1

Targets

O95180CACNA1H

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with ABT-639, and which of those have an active Phase 3 trial?

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