This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Flutemetamol
DrugBank Accession Number
DB15058
Background

Flutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 274.31
Monoisotopic: 274.057612319
Chemical Formula
C14H11FN2OS
Synonyms
Not Available

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
0F3M7032P5
CAS number
637003-10-2
InChI Key
VVECGOCJFKTUAX-UHFFFAOYSA-N
InChI
InChI=1S/C14H11FN2OS/c1-16-11-4-2-8(6-10(11)15)14-17-12-5-3-9(18)7-13(12)19-14/h2-7,16,18H,1H3
IUPAC Name
2-[3-fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol
SMILES
CNC1=C(F)C=C(C=C1)C1=NC2=C(S1)C=C(O)C=C2

References

General References
Not Available
ChemSpider
8282919
RxNav
1486026
ChEMBL
CHEMBL579205
ZINC
ZINC000034220093
Wikipedia
Flutemetamol_(18F)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedDiagnosticAlzheimer's Disease (AD) / Mild Cognitive Impairment (MCI)2
3CompletedDiagnosticBrain Fibrillarab Levels1
3CompletedDiagnosticHealthy Subjects (HS)1
3CompletedDiagnosticHydrocephalus, Normal Pressure1
3TerminatedDiagnosticAlzheimer's Disease (AD) / Dementia / Mild Cognitive Impairment (MCI)1
3TerminatedDiagnosticHydrocephalus, Normal Pressure1
2CompletedDiagnosticAlzheimer's Disease (AD) / Healthy Subjects (HS) / Mild Cognitive Impairment (MCI)1
2RecruitingDiagnosticBreast Cancer1
2Unknown StatusScreeningAlzheimer's Disease (AD)1
2, 3RecruitingDiagnosticAtherosclerosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionIntravenous150 MBq/ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0135 mg/mLALOGPS
logP4.16ALOGPS
logP3.45ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)9.23ChemAxon
pKa (Strongest Basic)2.89ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area45.15 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity84.62 m3·mol-1ChemAxon
Polarizability28.21 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:45 / Updated at June 12, 2020 16:53