This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Flutemetamol
- DrugBank Accession Number
- DB15058
- Background
Flutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Flutemetamol (DB15058)
- Weight
- Average: 274.31
Monoisotopic: 274.057612319 - Chemical Formula
- C14H11FN2OS
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 0F3M7032P5
- CAS number
- 637003-10-2
- InChI Key
- VVECGOCJFKTUAX-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H11FN2OS/c1-16-11-4-2-8(6-10(11)15)14-17-12-5-3-9(18)7-13(12)19-14/h2-7,16,18H,1H3
- IUPAC Name
- 2-[3-fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol
- SMILES
- CNC1=C(F)C=C(C=C1)C1=NC2=C(S1)C=C(O)C=C2
References
- General References
- Not Available
- External Links
- ChemSpider
- 8282919
- 1486026
- ChEMBL
- CHEMBL579205
- ZINC
- ZINC000034220093
- Wikipedia
- Flutemetamol_(18F)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Diagnostic Alzheimer's Disease (AD) / Mild Cognitive Impairment (MCI) 2 3 Completed Diagnostic Brain Fibrillarab Levels 1 3 Completed Diagnostic Healthy Subjects (HS) 1 3 Completed Diagnostic Hydrocephalus, Normal Pressure 1 3 Terminated Diagnostic Alzheimer's Disease (AD) / Dementia / Mild Cognitive Impairment (MCI) 1 3 Terminated Diagnostic Hydrocephalus, Normal Pressure 1 2 Completed Diagnostic Alzheimer's Disease (AD) / Healthy Subjects (HS) / Mild Cognitive Impairment (MCI) 1 2 Completed Screening Alzheimer's Disease (AD) 1 2 Recruiting Diagnostic Breast Cancer 1 2, 3 Unknown Status Diagnostic Atherosclerosis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, solution Intravenous 150 MBq/ml - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0135 mg/mL ALOGPS logP 4.16 ALOGPS logP 3.45 Chemaxon logS -4.3 ALOGPS pKa (Strongest Acidic) 9.23 Chemaxon pKa (Strongest Basic) 2.89 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 45.15 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 84.62 m3·mol-1 Chemaxon Polarizability 28.21 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at May 20, 2019 14:45 / Updated at June 12, 2020 16:53