Interferon alfa-2c

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Interferon alfa-2c
DrugBank Accession Number
DB15131
Background

Interferon alfa-2c is under investigation in clinical trial NCT00485563 (A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive Metastatic Renal Cell Carcinoma).

Type
Biotech
Groups
Investigational
Synonyms
  • Intron-A

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Interferon alfa-2c.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Interferon alfa-2c.
AcyclovirThe metabolism of Acyclovir can be decreased when combined with Interferon alfa-2c.
AgomelatineThe metabolism of Agomelatine can be decreased when combined with Interferon alfa-2c.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Interferon alfa-2c.
AlosetronThe metabolism of Alosetron can be decreased when combined with Interferon alfa-2c.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Interferon alfa-2c.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Interferon alfa-2c.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Interferon alfa-2c.
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Interferon alfa-2c.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
VW75A46X0K
CAS number
142192-09-4

References

General References
Not Available
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentMalignant Melanoma of Skin / Melanoma (Skin)1
3CompletedTreatmentAdjuvant Therapy / Melanomas1
2CompletedTreatmentLung Cancers1
2TerminatedTreatmentMalignancies / Melanomas1
2TerminatedTreatmentMelanomas1
2TerminatedTreatmentRenal Cell Adenocarcinoma1
2WithdrawnTreatmentMelanoma, Malignant / Melanomas1
1CompletedTreatmentMalignancies1
1, 2CompletedTreatmentMetastatic Melanoma1
Not AvailableCompletedNot AvailableMelanomas1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Delaporte E, Renton KW: Cytochrome P4501A1 and cytochrome P4501A2 are downregulated at both transcriptional and post-transcriptional levels by conditions resulting in interferon-alpha/beta induction. Life Sci. 1997;60(10):787-96. doi: 10.1016/s0024-3205(97)00006-4. [PubMed:9064483]

Drug created on May 20, 2019 14:52 / Updated on June 12, 2020 16:53