Pittsburgh Compound B

DB15161InvestigationalSmall molecule

Pittsburgh Compound B is under investigation in clinical trial NCT01723553 (Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD).

Chemical structure of Pittsburgh Compound B
Mechanism
Curator reviewed
Formula / weight
C14H12N2OS · 255.32 g/mol (avg)
Also known as
(N-methyl-(11C))2-(4'-methylaminophenyl)-6-hydroxybenzothiazole · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole · C-11 PiB

Resolves to

Compound
UNII7P55415B0RCAS566170-04-5ChEMBLCHEMBL207456
Structure
InChIKeyZQAQXZBSGZUUNL-BJUDXGSMSA-NSMILES[11CH3]NC1=CC=C(C=C1)C1=NC2=C(S1)C=C(O)C=C2
Targets
P05067APP

What you can answer from here — as of July 08, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
24Clinical trialsPhase, status and sponsor resolved per trial
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10+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Pittsburgh Compound B, and which of those have an active Phase 3 trial?

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