Pittsburgh Compound B

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Pittsburgh Compound B
DrugBank Accession Number
DB15161
Background

Pittsburgh Compound B is under investigation in clinical trial NCT01723553 (Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 255.32
Monoisotopic: 255.078468006
Chemical Formula
C14H12N2OS
Synonyms
  • (N-methyl-(11C))2-(4'-methylaminophenyl)-6-hydroxybenzothiazole
  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • C-11 PiB

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7P55415B0R
CAS number
566170-04-5
InChI Key
ZQAQXZBSGZUUNL-BJUDXGSMSA-N
InChI
InChI=1S/C14H12N2OS/c1-15-10-4-2-9(3-5-10)14-16-12-7-6-11(17)8-13(12)18-14/h2-8,15,17H,1H3/i1-1
IUPAC Name
2-{4-[(11C)methylamino]phenyl}-1,3-benzothiazol-6-ol
SMILES
[11CH3]NC1=CC=C(C=C1)C1=NC2=C(S1)C=C(O)C=C2

References

General References
Not Available
ChemSpider
2104829
ChEMBL
CHEMBL207456

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Enrolling by InvitationDiagnosticAlzheimer's Disease (AD) / Dementia, Vascular / Diffuse Lewy Body Disease / Frontotemporal Dementia1
4Enrolling by InvitationDiagnosticDiffuse Lewy Body Disease1
2CompletedBasic ScienceAlzheimer's Disease (AD)1
2CompletedDiagnosticAlzheimer's Disease (AD)1
1CompletedBasic ScienceAlzheimer's Disease (AD)1
1CompletedDiagnosticAlzheimer's Disease (AD)1
1CompletedDiagnosticAphasia / Aphasia, Non-fluent / Apraxia of Speech / PPA / Primary Progressive Aphasia(PPA) / Primary Progressive Nonfluent Aphasia / Progressive Aphasia / Semantic Dementia1
1CompletedDiagnosticAtypical Alzheimers Disease / Logopenic Variant of Primary Progressive Aphasia (LPA) / Posterior Cortical Atrophy (PCA)1
0CompletedBasic ScienceAlcohol Use Disorder (AUD)1
0Enrolling by InvitationDiagnosticAlzheimer's Disease (AD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0162 mg/mLALOGPS
logP4.11ALOGPS
logP3.31ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)9.23ChemAxon
pKa (Strongest Basic)3.65ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area45.15 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity84.4 m3·mol-1ChemAxon
Polarizability28.12 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 14:55 / Updated on June 12, 2020 16:53