This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Fosmanogepix
- DrugBank Accession Number
- DB15183
- Background
Fosmanogepix is under investigation in clinical trial NCT03604705 (An Efficacy and Safety Study of APX001 in Non-Neutropenic Patients With Candidemia).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Fosmanogepix (DB15183)
- Weight
- Average: 468.406
Monoisotopic: 468.11987141 - Chemical Formula
- C22H21N4O6P
- Synonyms
- Fosmanogepix
- External IDs
- APX001
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 1XQ871489P
- CAS number
- 2091769-17-2
- InChI Key
- JQONJQKKVAHONF-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H21N4O6P/c23-22-19(4-3-11-26(22)15-31-33(27,28)29)20-13-18(25-32-20)12-16-6-8-17(9-7-16)14-30-21-5-1-2-10-24-21/h1-11,13,23H,12,14-15H2,(H2,27,28,29)
- IUPAC Name
- 2-amino-1-[(hydrogen phosphonatooxy)methyl]-3-[3-({4-[(pyridin-2-yloxy)methyl]phenyl}methyl)-1,2-oxazol-5-yl]pyridin-1-ium
- SMILES
- NC1=C(C=CC=[N+]1COP(O)([O-])=O)C1=CC(CC2=CC=C(COC3=NC=CC=C3)C=C2)=NO1
References
- General References
- Not Available
- External Links
- ChemSpider
- 64853722
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Candidemia 1 2 Terminated Treatment Candidemia / Candidiasis / Invasive Candidiases 1 2 Terminated Treatment Invasive Fungal Infections 1 1 Completed Basic Science Invasive Fungal Infections 1 1 Completed Other Acute Myeloid Leukemia 1 1 Completed Treatment Fungal Infections 4 1 Recruiting Basic Science Hepatic Impairment 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0209 mg/mL ALOGPS logP 1.13 ALOGPS logP -4.2 Chemaxon logS -4.4 ALOGPS pKa (Strongest Acidic) 0.44 Chemaxon pKa (Strongest Basic) 3.87 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 147.64 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 119.86 m3·mol-1 Chemaxon Polarizability 46.35 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at May 20, 2019 14:57 / Updated at February 21, 2021 18:55