NAV

JNJ-26489112

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
JNJ-26489112
DrugBank Accession Number
DB15203
Background

JNJ-26489112 is under investigation in clinical trial NCT00579384 (A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 278.71
Monoisotopic: 278.0128057
Chemical Formula
C9H11ClN2O4S
Synonyms
Not Available
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Integrate drug-drug
interactions in your software
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with JNJ-26489112.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with JNJ-26489112.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with JNJ-26489112.
AgomelatineThe risk or severity of CNS depression can be increased when Agomelatine is combined with JNJ-26489112.
AlfentanilThe risk or severity of CNS depression can be increased when Alfentanil is combined with JNJ-26489112.
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
G1TI012DLT
CAS number
871824-55-4
InChI Key
KXSAIQPPGSSNKX-ZETCQYMHSA-N
InChI
InChI=1S/C9H11ClN2O4S/c10-6-1-2-8-9(3-6)15-5-7(16-8)4-12-17(11,13)14/h1-3,7,12H,4-5H2,(H2,11,13,14)/t7-/m0/s1
IUPAC Name
N-{[(2S)-6-chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}aminosulfonamide
SMILES
NS(=O)(=O)NC[C@H]1COC2=C(O1)C=CC(Cl)=C2

References

General References
Not Available
ChemSpider
9790860
BindingDB
50444089
ChEMBL
CHEMBL3092995
Wikipedia
JNJ-26489112

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentPhotosensitive Epilepsy1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.9 mg/mLALOGPS
logP1.31ALOGPS
logP0.21Chemaxon
logS-2.2ALOGPS
pKa (Strongest Acidic)10.21Chemaxon
pKa (Strongest Basic)0.23Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area90.65 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity61.26 m3·mol-1Chemaxon
Polarizability25.58 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0090000000-e478ad15e75e343c9ab6
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004l-9060000000-f8efee37092c9d17eddf
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004l-9010000000-7ec70b01302a215f5589
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-01si-2890000000-c95a754e9f198304262c
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0059-9100000000-0699e39f08cbef3a4606
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-01r6-9500000000-ab993626f71033390e70
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at May 20, 2019 14:59 / Updated at June 12, 2020 16:53