Fluciclovine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Fluciclovine
- DrugBank Accession Number
- DB15237
- Background
Fluciclovine is under investigation in clinical trial NCT03036943 (Fluciclovine (18F) Imaging of Breast Cancer).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 133.122
Monoisotopic: 133.053906665 - Chemical Formula
- C5H8FNO2
- Synonyms
- Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid
- Cyclobutanecarboxylic acid, 1-amino-3-fluoro-, trans-
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- YKG0YF688X
- CAS number
- 222727-43-7
- InChI Key
- NTEDWGYJNHZKQW-IWLYVCSRSA-N
- InChI
- InChI=1S/C5H8FNO2/c6-3-1-5(7,2-3)4(8)9/h3H,1-2,7H2,(H,8,9)/t3-,5-
- IUPAC Name
- (1r,3r)-1-amino-3-fluorocyclobutane-1-carboxylic acid
- SMILES
- N[C@]1(C[C@H](F)C1)C(O)=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 28487364
- 2571859
- ChEBI
- 176400
- ChEMBL
- CHEMBL1908917
- ZINC
- ZINC000100070937
- Wikipedia
- Fluciclovine_(18F)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Diagnostic Prostate Cancer 2 2 Completed Diagnostic Cancer 1 2 Completed Diagnostic Prostate Cancer 2 2 Not Yet Recruiting Diagnostic Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype 1 2 Recruiting Diagnostic Brain Cancer / Brain Metastases 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 173.0 mg/mL ALOGPS logP -3 ALOGPS logP -2.9 Chemaxon logS 0.11 ALOGPS pKa (Strongest Acidic) 2.07 Chemaxon pKa (Strongest Basic) 9.42 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 63.32 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 27.75 m3·mol-1 Chemaxon Polarizability 11.65 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-9100000000-10cfdfda5bd301d52b0d Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-00y1-9100000000-18b2fb07bac4d2cdba5e Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-001i-0900000000-cd5988cd08de5aa795a6 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0159-9700000000-7bb228f93147807f66bc Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0007-9000000000-f52f81bef893fd7cc131 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-06y7-9000000000-4e230d26b14c008a646f Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 20, 2019 15:03 / Updated at December 01, 2022 11:29