Fluciclovine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Fluciclovine
DrugBank Accession Number
DB15237
Background

Fluciclovine is under investigation in clinical trial NCT03036943 (Fluciclovine (18F) Imaging of Breast Cancer).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 133.122
Monoisotopic: 133.053906665
Chemical Formula
C5H8FNO2
Synonyms
  • Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid
  • Cyclobutanecarboxylic acid, 1-amino-3-fluoro-, trans-

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
YKG0YF688X
CAS number
222727-43-7
InChI Key
NTEDWGYJNHZKQW-IWLYVCSRSA-N
InChI
InChI=1S/C5H8FNO2/c6-3-1-5(7,2-3)4(8)9/h3H,1-2,7H2,(H,8,9)/t3-,5-
IUPAC Name
(1r,3r)-1-amino-3-fluorocyclobutane-1-carboxylic acid
SMILES
N[C@]1(C[C@H](F)C1)C(O)=O

References

General References
Not Available
ChemSpider
28487364
RxNav
2571859
ChEBI
176400
ChEMBL
CHEMBL1908917
ZINC
ZINC000100070937
Wikipedia
Fluciclovine_(18F)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedDiagnosticProstate Cancer2
2CompletedDiagnosticCancer1
2CompletedDiagnosticProstate Cancer2
2Not Yet RecruitingDiagnosticGlioblastoma IDH (Isocitrate Dehydrogenase) Wildtype1
2RecruitingDiagnosticBrain Cancer / Brain Metastases1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility173.0 mg/mLALOGPS
logP-3ALOGPS
logP-2.9Chemaxon
logS0.11ALOGPS
pKa (Strongest Acidic)2.07Chemaxon
pKa (Strongest Basic)9.42Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area63.32 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity27.75 m3·mol-1Chemaxon
Polarizability11.65 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-9100000000-10cfdfda5bd301d52b0d
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00y1-9100000000-18b2fb07bac4d2cdba5e
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-0900000000-cd5988cd08de5aa795a6
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0159-9700000000-7bb228f93147807f66bc
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0007-9000000000-f52f81bef893fd7cc131
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-06y7-9000000000-4e230d26b14c008a646f
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at May 20, 2019 15:03 / Updated at December 01, 2022 11:29