Fluciclovine

DB15237InvestigationalSmall molecule

Fluciclovine is under investigation in clinical trial NCT03036943 (Fluciclovine (18F) Imaging of Breast Cancer).

Mechanism: Pharmacologically active on Large neutral amino acids transporter small subunit 1 and Neutral amino acid transporter B(0)
Curator reviewed
Formula / weight: C₅H₈FNO₂ · 133.122 g/mol (avg)
Also known as: Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid · Cyclobutanecarboxylic acid, 1-amino-3-fluoro-, trans- · FACBC

Resolves to

Compound

UNIIYKG0YF688XCAS222727-43-7ChEMBLCHEMBL1908917ChEBI176400

Clinical / RWD

RxNorm2571859

Structure

InChIKeyNTEDWGYJNHZKQW-IWLYVCSRSA-NSMILESN[C@]1(C[C@H](F)C1)C(O)=O

Targets

Q01650SLC7A5Q15758SLC1A5

Transporters

Q01650SLC7A5Q15758SLC1A5Q9Y6L6SLCO1B1P08183ABCB1Q4U2R8SLC22A6O15439ABCC4O15244SLC22A2

What you can answer from here — as of July 10, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

7TransportersSubstrate / inhibitor direction, not just membership

Listed above

11Clinical trialsPhase, status and sponsor resolved per trial

19+ReferencesStructured and connected to the statements they support

Which drugs share a target with Fluciclovine, and which of those have an active Phase 3 trial?

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