Olinciguat

DB15238InvestigationalSmall molecule

Olinciguat is under investigation in clinical trial NCT03892499 (A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat...

Mechanism: Pharmacologically active on Guanylate cyclase
Curator reviewed
Formula / weight: C₂₁H₁₆F₅N₇O₃ · 509.397 g/mol (avg)
Code names: IW-1701

Resolves to

Compound

UNIIPD5F4ZXD21CAS1628732-62-6

Structure

InChIKeyYWQFJNWMWZMXRW-HXUWFJFHSA-NSMILESNC(=O)[C@](O)(CNC1=C(F)C=NC(=N1)C1=NN(CC2=C(F)C=CC=C2)C(=C1)C1=NOC=C1)C(F)(F)F

Targets

Q9BQB4SOST

What you can answer from here — as of July 08, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Olinciguat, and which of those have an active Phase 3 trial?

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