Methylsamidorphan

DB15241InvestigationalSmall molecule

Methylsamidorphan is under investigation in clinical trial NCT01418092 (ALK37-007: Evaluation of Safety and Efficacy of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation (OIC)).

Mechanism: Pharmacologically active on Mu-type opioid receptor
Curator reviewed
Formula / weight: C₂₂H₂₉N₂O₄ · 385.483 g/mol (avg)
Code names: ALKS 37

Resolves to

Compound

UNII8347HC35J6CAS1119361-12-4ChEMBLCHEMBL2364619

Structure

InChIKeyATCVVCBJNHXIEX-ZAHKBLQYSA-OSMILESC[N@+]1(CC2CC2)CC[C@]23CC(=O)CC[C@@]2(O)[C@H]1CC1=C3C(O)=C(C=C1)C(N)=O

Targets

P35372OPRM1

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Methylsamidorphan, and which of those have an active Phase 3 trial?

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