This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
NM-404 I-131
DrugBank Accession Number
DB15244
Background

NM-404 I-131 is under investigation in clinical trial NCT01495663 (Dose Escalation Study of I-131-CLR1404 in Subjects With Cancer That Does Not Respond to Treatment or Has Returned).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 641.626
Monoisotopic: 641.277345357
Chemical Formula
C29H53INO4P
Synonyms
  • I-131-CLR1404

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
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Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Avoid life-threatening adverse drug events & improve clinical decision support.
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
R048696O9L
CAS number
873438-88-1
InChI Key
ZOAIEFWMQLYMTF-YRKXUXMHSA-N
InChI
InChI=1S/C29H53INO4P/c1-31(2,3)25-27-35-36(32,33)34-26-19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20-28-21-23-29(30)24-22-28/h21-24H,4-20,25-27H2,1-3H3/i30+4
IUPAC Name
18-[4-(¹³¹I)iodophenyl]octadecyl 2-(trimethylazaniumyl)ethyl phosphate
SMILES
C[N+](C)(C)CCOP([O-])(=O)OCCCCCCCCCCCCCCCCCCC1=CC=C([131I])C=C1

References

General References
Not Available
ChemSpider
13173778

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentCentral Nervous System Lymphoma / Chronic Lymphocytic Leukemia (CLL) / Diffuse Large B-Cell Lymphoma (DLBCL) / Lymphoplasmacytic Lymphoma / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma (MZL) / Multiple Myeloma (MM) / Small Lymphocytic Lymphoma / Waldenström's Macroglobulinemia (WM)1
2WithdrawnTreatmentGliomas1
1Active Not RecruitingTreatmentMultiple Myeloma (MM)1
1CompletedBasic ScienceTumors, Solid1
1CompletedTreatmentMalignancies1
1RecruitingTreatmentDIPG / Ewing's Sarcoma / Neuroblastoma (NB) / Pediatric Brain Tumors / Pediatric Lymphoma / Rhabdomyosarcomas / Sarcoma, Osteogenic / Solid Tumor Pediatric1
1RecruitingTreatmentHead and Neck Carcinoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.06e-05 mg/mLALOGPS
logP4.38ALOGPS
logP5.65ChemAxon
logS-7.8ALOGPS
pKa (Strongest Acidic)1.88ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area58.59 Å2ChemAxon
Rotatable Bond Count24ChemAxon
Refractivity172.77 m3·mol-1ChemAxon
Polarizability69.9 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 15:03 / Updated at June 12, 2020 16:53