ONO-8539

DB15325InvestigationalSmall molecule

ONO-8539 is under investigation in clinical trial NCT01707901 (A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Disease).

Mechanism: Pharmacologically active on Prostaglandin E2 receptor EP1 subtype
Curator reviewed
Formula / weight: C₂₅H₂₈N₂O₅S₂ · 500.63 g/mol (avg)
Code names: ONO-8539

Resolves to

Compound

UNII94W010PZ1ZCAS459842-29-6ChEMBLCHEMBL3912251

Structure

InChIKeyALLLQQUASFFEKP-UHFFFAOYSA-NSMILESCC(C)CN(C1=CC2=C(CCC2)C=C1OCC1=CC=C(C=C1C)C(O)=O)S(=O)(=O)C1=NC=CS1

Targets

P34995PTGER1

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with ONO-8539, and which of those have an active Phase 3 trial?

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