Carfentanil, C-11

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Carfentanil, C-11
DrugBank Accession Number
DB15360
Background

Carfentanil, C-11 is under investigation in clinical trial NCT01899170 (Towards Individualized Deep Brain Stimulation Treatment of Chronic Neuropathic Pain).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 393.515
Monoisotopic: 393.237076652
Chemical Formula
C24H30N2O3
Synonyms
  • 11C-CARFENTANIL

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of adverse effects can be increased when Carfentanil, C-11 is combined with 1,2-Benzodiazepine.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Carfentanil, C-11.
AcetophenazineThe risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Carfentanil, C-11.
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Carfentanil, C-11.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Carfentanil, C-11.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Carfentanil, C-11.
AlimemazineThe risk or severity of hypotension and CNS depression can be increased when Alimemazine is combined with Carfentanil, C-11.
AlloinThe therapeutic efficacy of Alloin can be decreased when used in combination with Carfentanil, C-11.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Carfentanil, C-11.
AlosetronThe risk or severity of adverse effects can be increased when Alosetron is combined with Carfentanil, C-11.
Interactions
Identify potential medication risks
Easily compare up to 40 drugs with our drug interaction checker.
Get severity rating, description, and management advice.
Learn more
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
UVI40IC2GN
CAS number
98598-83-5
InChI Key
YDSDEBIZUNNPOB-JVVVGQRLSA-N
InChI
InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3/i2-1
IUPAC Name
(11C)methyl 1-(2-phenylethyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate
SMILES
CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC2=CC=CC=C2)CC1)C(=O)O[11CH3]

References

General References
Not Available
ChemSpider
396157
ChEMBL
CHEMBL2311157

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2TerminatedTreatmentNeuralgia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0259 mg/mLALOGPS
logP3.7ALOGPS
logP3.67ChemAxon
logS-4.2ALOGPS
pKa (Strongest Basic)8.05ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area49.85 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity114.38 m3·mol-1ChemAxon
Polarizability43.78 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 15:19 / Updated on June 12, 2020 16:53