Sisunatovir
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Sisunatovir
- DrugBank Accession Number
- DB15674
- Background
Sisunatovir is under investigation in clinical trial NCT04267822 (Study of RV521 in the Treatment of Adult Subjects Who Have Undergone HCT With an URTI With RSV).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 446.45
Monoisotopic: 446.172973996 - Chemical Formula
- C23H22F4N4O
- Synonyms
- Sisunatovir
- External IDs
- RV-521
- RV521
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- KE63TTO7WK
- CAS number
- 1903763-82-5
- InChI Key
- JOPCJJSYRPUEDS-UHFFFAOYSA-N
- InChI
- InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2
- IUPAC Name
- 1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-1,3-benzodiazol-2-yl]methyl}-6'-fluoro-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one
- SMILES
- NCC1=CC2=C(C=C1)N(CCCC(F)(F)F)C(CN1C(=O)C3(CC3)C3=C1C=C(F)C=C3)=N2
References
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Respiratory Syncytial Virus (RSV) Infection 1 2 Terminated Treatment Lower Resp Tract Infection / Respiratory Syncytial Virus (RSV) 1 2 Withdrawn Treatment Lower Resp Tract Infection / Respiratory Syncytial Virus (RSV) Infection / Stem Cell Transplant Complications 1 2, 3 Recruiting Treatment Respiratory Syncytial Virus (RSV) Infection 1 1 Active Not Recruiting Basic Science Healthy Volunteers (HV) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00653 mg/mL ALOGPS logP 3 ALOGPS logP 3.66 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 9.08 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 64.15 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 111.07 m3·mol-1 Chemaxon Polarizability 44.17 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0002-0000900000-b455bd2b2cb2aa64b846 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0000900000-785b232c787e7782bba3 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-000t-0000900000-a5aed08a8d28a67edd6f Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-00kb-1024900000-d12d63f646e80d7996cb Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-00fs-0448900000-b162290c33df5d5c825f Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-01dv-0669200000-04f2bc538a519041cd05 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at April 20, 2020 15:50 / Updated at February 21, 2021 18:55