These cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF. Chimeric antigen receptors... Chimeric antigen receptors (CARs) are artificial receptors consisting of an antibody-derived antigen binding domain and transmembrane and signaling domains from T-cell receptor signalling moieties.
- Mechanism
- Curator reviewed
NK cells modified by CARs play a role in targeted immunotherapy without subsequent cytokine release syndrome or neurotoxicity as these effects are mediated through GM-CSF neutralization. The NKG2D-ACE2 CAR-NK cells secreting super IL15 superagonist and GM-CSF neutralizing scFv is thought to act synergistically to target and kill cells infected with SARS-Cov-2 without widespread cytokine release and inflammation.
- Also known as
- ACE2 CAR-Natural Killer Cell · ACE2 CAR-NK Cell · NKG2D CAR-Natural Killer Cell · NKG2D CAR-NK Cell · NKG2D-ACE2 CAR-Natural Killer Cell
- Code names
- NKG2D-ACE2 CAR-NK Cell
What you can answer from here — as of June 19, 2026
Which companies are running trials of NKG2D-ACE2 CAR-NK Cell, in which indications and phases, and which of those programs are still active?
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