NAV

Dental Mesenchymal Pulp Stem Cells

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Dental Mesenchymal Pulp Stem Cells
DrugBank Accession Number
DB15737
Background

Dental pulp is a soft, connective tissue present in the dental crown of both third molar and first premolar teeth. Dental pulp stem cells (DPSCs) exhibit fibro-blast like plasticity and adherent properties. They are harvested through surgical extraction of wisdom teeth from adults; this procedure is favoured as it is non-invasive, easily accessible, and allows for an alternate use of teeth that are usually discarded. DPSCs can remain stable in media once extracted, and have a high proliferation and regeneration capacity.

DPSCs have multiple properties, and express surface antigens like CD90, CD29, and CD105 but not CD14 or CD45. They also express specific pluripotency markers like MYC and SOX2 which can be absent in other MSCs. These cells have innate neurogenic potential as their origins are traced to the embryonic neural crest; there is potential for these cells to create neurons and glial cells. In addition, they are able to differentiate into chondrocytes, adipocytes, and odontoblasts under appropriate conditions.

Type
Biotech
Groups
Investigational
Biologic Classification
Cell transplant therapies
Other cell transplant therapies
Synonyms
  • Allogenic Human Dental Pulp Stem Cells
  • BSH BTC
  • Dental Pulp Mesenchymal Stem Cells
  • hDPSC
  • Utooth BTC
External IDs
  • Dental Mesenchymal Pulp Stem Cells
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

DPCSs exert many functions, including tissue development, homeostasis, and tissue repair. They are able to secrete pro-angiogenic and anti-apoptotic factors, and are implicated in the treatment of conditions like osteoarthritis, myocardial infarction, and Alzheimer’s disorder. DPSCs are currently being used to address the cellular effects of infection with COVID-19.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Dave JR, Tomar GB: Dental Tissue-Derived Mesenchymal Stem Cells: Applications in Tissue Engineering. Crit Rev Biomed Eng. 2018;46(5):429-468. doi: 10.1615/CritRevBiomedEng.2018027342. [Article]
  2. Mortada I, Mortada R, Al Bazzal M: Dental Pulp Stem Cells and Neurogenesis. Adv Exp Med Biol. 2018;1083:63-75. doi: 10.1007/5584_2017_71. [Article]
  3. Nuti N, Corallo C, Chan BM, Ferrari M, Gerami-Naini B: Multipotent Differentiation of Human Dental Pulp Stem Cells: a Literature Review. Stem Cell Rev Rep. 2016 Oct;12(5):511-523. doi: 10.1007/s12015-016-9661-9. [Article]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19)1
0Unknown StatusTreatmentCoronavirus Disease 2019 (COVID‑19)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at August 11, 2020 20:45 / Updated at December 02, 2020 11:50