Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells
Accession Number
DB15740
Description

Human olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) reside in an accessible location of the nasal cavity and have properties of multipotency and high proliferation, which contributes to high potential for regenerative medicine. In humans, OM-MSCs are derived from the olfactory mucosa which is collected in vivo through rhinoscopy techniques and nasal forceps. OM-MSCs are also immunomodulatory and have potential for treating immunological diseases. Currently, OM-MSCs does not have wide application as there is not yet a standard and unambiguous protocol for OM-MSC collection, isolation, and therapeutic application.

Type
Biotech
Groups
Investigational
Biologic Classification
Cell transplant therapies
Other cell transplant therapies
Synonyms
  • hOM-MSC
  • Olfactory mucosa mesenchymal stem cells
  • Olfactory mucosa mesenchymal stem/stromal cells
  • Olfactory mucosa mesenchymal stromal cells
  • OM-MSC
External IDs
  • Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action

OM-MSCs’ immunomodulating activities are partially related to CD4+ T-lymphocytes, B-lymphocytes, macrophages, and dendritic cells. OM-MSCs were also found to suppress cytotoxic functions of CD8 + cytotoxic lymphocytes and natural killer cells. Potential applications include in the field of experimental neurology to employ it for treatment of different types of lesions and neurodegenerative diseases of the central nervous system, hippocampal lesions, regeneration of peripheral nerves and cranial nerves, and for spinal cord trauma. There are also potentials for immunosuppression for autoimmune diseases and regenerative promotion for myocardial tissue after infarction and also against ischemic tissues.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Not Available
Classification
Not classified

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Alvites RD, Branquinho MV, Caseiro AR, Amorim I, Santos Pedrosa S, Rema A, Faria F, Porto B, Oliveira C, Teixeira P, Magalhaes R, Geuna S, Varejao ASP, Mauricio AC: Rat Olfactory Mucosa Mesenchymal Stem/Stromal Cells (OM-MSCs): A Characterization Study. Int J Cell Biol. 2020 Jan 29;2020:2938258. doi: 10.1155/2020/2938258. eCollection 2020. [PubMed:32411249]
  2. Company Article [Link]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2Not Yet RecruitingTreatmentCOVID / COVID - 19 / Infections, Coronavirus / Novel Coronavirus Infectious Disease (COVID-19) / Pneumonia / Pneumonitis, Interstitial / Viral Pneumonia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on August 11, 2020 14:55 / Updated on August 13, 2020 01:02

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