Human olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) reside in an accessible location of the nasal cavity and have properties of multipotency and high proliferation, which contributes to high potential for... In humans, OM-MSCs are derived from the olfactory mucosa which is collected in vivo through rhinoscopy techniques and nasal forceps.
- Mechanism
- Curator reviewed
OM-MSCs’ immunomodulating activities are partially related to CD4+ T-lymphocytes, B-lymphocytes, macrophages, and dendritic cells. OM-MSCs were also found to suppress cytotoxic functions of CD8 + cytotoxic lymphocytes and natural killer cells. Potential applications include in the field of experimental neurology to employ it for treatment of different types of lesions and neurodegenerative diseases of the central nervous system, hippocampal lesions, regeneration of peripheral nerves and cranial nerves, and for spinal cord trauma. There are also potentials for immunosuppression for autoimmune diseases and regenerative promotion for myocardial tissue after infarction and also against ischemic tissues.
- Also known as
- hOM-MSC · Olfactory mucosa mesenchymal stem cells · Olfactory mucosa mesenchymal stem/stromal cells · Olfactory mucosa mesenchymal stromal cells · OM-MSC
- Code names
- Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells
What you can answer from here — as of August 13, 2020
Which companies are running trials of Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells, in which indications and phases, and which of those programs are still active?
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