Mesenchymal stem cells (MSCs) exert their therapeutic effects through multiple modalities, including paracrine factors such as exosomes. Exosomes are nanometer-sized, membrane-bound vesicles secreted for the purpose of cell-cell communication. Once... Once secreted into extracellular fluid, exosomes are taken up by their target cells or carried to distant target sites.
- Mechanism
- Curator reviewed
Exosomes are a novel cell-therapy currently investigated for the treatment of liver, kidney, cardiovascular, and neurological disease. They are messengers in intercellular communication through their ability to secrete bioactive lipids, proteins, and RNAs to target sites. As they can carry unique proteins and cytokines, exosomes are involved in both physiological and pathological processes. Therapeutically, MSC-derived exosomes can restore tissue homeostasis, and enable tissue recovery, repair, and regeneration.
- Also known as
- DB-001 · Stem-cell derived exosome vesicles · Stem-cell derived extracellular vesicle products · Stem-cell derived extracellular vesicles
- Code names
- Stem-cell derived exosome vesicle products
What you can answer from here — as of March 06, 2025
Which companies are running trials of Stem-cell derived exosome vesicle products, in which indications and phases, and which of those programs are still active?
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