Cardiosphere-derived cells (CDCs) are derived from human neonatal heart tissue with a distinct antigenic profile (CD105+, CD45-, and CD90low). They exert their effects by secreting exosomes: nanometer-sized, membrane-bound vesicles used... CDCs target multiple cytokine pathways associated with poor outcomes (e.g.
- Mechanism
- Curator reviewed
Cardiosphere-derived cell exosomes can reduce cardiac scar size, improve myocardial function, and attenuate damaging remodeling that occurs from infections. CAP-1002 was formulated as an intravenous infusion of cardiosphere-derived cells and is currently being investigated as a treatment for critically ill COVID-19 patients.
- Code names
- CAP-1002 · CAP-1002A · CAP-1002B
Resolves to
What you can answer from here — as of November 13, 2025
Which companies are running trials of Allogeneic Cardiosphere-Derived Cells, in which indications and phases, and which of those programs are still active?
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