Identification
- Generic Name
- Washed Microbiota Transplantation
- DrugBank Accession Number
- DB15745
- Background
Fecal microbiota transplantation (FMT) is effective in enhancing the gut microbiota of patients experiencing a high range of disease states, including Clostridioides difficile (C. diff) infection, Crohn’s disease, and ulcerative colitis. Washed microbiota preparation (WMT) involves a method wherein FMT is used, but the preparation undergoes microfiltration through an automatic purification system combined with repeated centrifugation and suspension. Fecal particles, parasite eggs, fungus and other potentially harmful things are removed. The resulting suspension is shown to decrease FMT-related adverse events.
- Type
- Biotech
- Groups
- Investigational
- Synonyms
- WMT
- External IDs
- Washed Microbiota Transplantation
Pharmacology
- Indication
Not Available
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Not Available
- Mechanism of action
WMT delivers a precise dose of enriched microbiota through intraperitoneal injection, oral capsule, nasogastric tube, nasojeunal tube, or anal enema. The transplantation of the materials within the WMT is thought to recolonize the gut bacteria and aid in treating patient pathology associated with disease like Crohn’s, and ulcerative colitis. WMT is being investigated as a rescue therapy for critically ill patients with COVID-19.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
References
- General References
- Zhang T, Lu G, Zhao Z, Liu Y, Shen Q, Li P, Chen Y, Yin H, Wang H, Marcella C, Cui B, Cheng L, Ji G, Zhang F: Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening. Protein Cell. 2020 Apr;11(4):251-266. doi: 10.1007/s13238-019-00684-8. Epub 2020 Jan 9. [Article]
- Zhang FM, Liu YF: [Evidence and decision of the choice of delivery way in washed microbiota transplantation]. Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Jul 10;23(Z1):45-47. doi: 10.3760/cma.j.cn.441530-20200507-00259. [Article]
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Not Yet Recruiting Treatment Autism Disorder 1 1, 2 Recruiting Treatment Constipation 1 Not Available Not Yet Recruiting Treatment Rhinitis 1 Not Available Recruiting Treatment CKD 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at August 11, 2020 21:22 / Updated at August 13, 2020 07:02