Washed Microbiota Transplantation

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Washed Microbiota Transplantation
Accession Number
DB15745
Description

Fecal microbiota transplantation (FMT) is effective in enhancing the gut microbiota of patients experiencing a high range of disease states, including Clostridioides difficile (C. diff) infection, Crohn’s disease, and ulcerative colitis. Washed microbiota preparation (WMT) involves a method wherein FMT is used, but the preparation undergoes microfiltration through an automatic purification system combined with repeated centrifugation and suspension. Fecal particles, parasite eggs, fungus and other potentially harmful things are removed. The resulting suspension is shown to decrease FMT-related adverse events.

Type
Biotech
Groups
Investigational
Synonyms
  • WMT
External IDs
  • Washed Microbiota Transplantation

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action

WMT delivers a precise dose of enriched microbiota through intraperitoneal injection, oral capsule, nasogastric tube, nasojeunal tube, or anal enema. The transplantation of the materials within the WMT is thought to recolonize the gut bacteria and aid in treating patient pathology associated with disease like Crohn’s, and ulcerative colitis. WMT is being investigated as a rescue therapy for critically ill patients with COVID-19.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Not Available
Classification
Not classified

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Zhang T, Lu G, Zhao Z, Liu Y, Shen Q, Li P, Chen Y, Yin H, Wang H, Marcella C, Cui B, Cheng L, Ji G, Zhang F: Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening. Protein Cell. 2020 Apr;11(4):251-266. doi: 10.1007/s13238-019-00684-8. Epub 2020 Jan 9. [PubMed:31919742]
  2. Zhang FM, Liu YF: [Evidence and decision of the choice of delivery way in washed microbiota transplantation]. Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Jul 10;23(Z1):45-47. doi: 10.3760/cma.j.cn.441530-20200507-00259. [PubMed:32594725]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on August 11, 2020 15:22 / Updated on August 13, 2020 01:02

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