Interferon kappa is a subclass of type I interferon mediating host defence which consists of 207 amino acids and has 30% homology with others of the same class as it... This gene encoding for this interferon is expressed in human epidermal keratinocytes.
- Mechanism
- Curator reviewed
Significant interferon kappa expression enhancement occurs with: viral infection, exposure to double-stranded RNA, or treatment with interferon gamma or interferon beta. It was also found cellular protection against viral infection occurs in a species-specific manner. The mechanism by which IFN-κ acts involves the activation of the interferon-stimulated response element signalling pathway and a panel of genes which include anti-viral mediators and transcriptional regulators, similar to those regulated by other type I interferons. Also as with other type I interferons, IFN-κ binds at the same receptors, which are interferon-α/β receptor 1(IFNAR1) and IFNAR2.
- Also known as
- IFN‐κ
- Code names
- Interferon Kappa
What you can answer from here — as of March 06, 2025
Which companies are running trials of Interferon Kappa, in which indications and phases, and which of those programs are still active?
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