Sulbactam pivoxil

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Sulbactam pivoxil is a prodrug of a beta-lactamase inhibitor used to improve the efficacy of beta lactam antibiotics

Generic Name
Sulbactam pivoxil
DrugBank Accession Number
DB15761
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 347.38
Monoisotopic: 347.103873194
Chemical Formula
C14H21NO7S
Synonyms
  • Pivsulbactam
  • Sulbactam pivoxil
  • Sulbactam pivoxyl
External IDs
  • CP 47904
  • CP-47,904
  • CP-47904

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatBacterial infectionsCombination Product in combination with: Amoxicillin (DB01060)••••••••••••
Contraindications & Blackbox Warnings
Prevent Adverse Drug Events Today
Tap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events with our Clinical API
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!
See the data
Improve decision support & research outcomes with our structured adverse effects data.
See a data sample
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
EUMOXIN DUO FORTESulbactam pivoxil (5 g) + Amoxicillin Trihydrate (20 g)Powder, for suspensionOralSERVICIO TECNICO GONHER FARMACEUTICA LTDA.2008-10-15Not applicableColombia flag
EUMOXIN® DUO FORTESulbactam pivoxil (125 mg) + Amoxicillin (875 mg)Tablet, coatedOralSERVICIO TECNICO GONHER FARMACEUTICA LTDA.2008-06-20Not applicableColombia flag
TRIFAMOX IBL DUO® COMPRIMIDOSSulbactam pivoxil (125 mg) + Amoxicillin Trihydrate (875 mg)Tablet, film coatedOralSYNTOPHARMA S.A. PLANTA PENICILINAS2006-11-102021-04-01Colombia flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
2X0WTA96KX
CAS number
69388-79-0
InChI Key
OHPVYKXTRACOSQ-ZJUUUORDSA-N
InChI
InChI=1S/C14H21NO7S/c1-13(2,3)12(18)22-7-21-11(17)10-14(4,5)23(19,20)9-6-8(16)15(9)10/h9-10H,6-7H2,1-5H3/t9-,10+/m1/s1
IUPAC Name
[(2S,5R)-3,3-dimethyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carbonyloxy]methyl 2,2-dimethylpropanoate
SMILES
[H][C@@]12CC(=O)N1[C@@H](C(=O)OCOC(=O)C(C)(C)C)C(C)(C)S2(=O)=O

References

General References
  1. Trifamox IBL Duo Product Information [Link]
ChemSpider
8173402
RxNav
166010
ChEBI
135467
ChEMBL
CHEMBL423875
ZINC
ZINC000004217478

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, coatedOral
Tablet, film coatedOral
Powder, for suspensionOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.3 mg/mLALOGPS
logP0.64ALOGPS
logP0.92Chemaxon
logS-2.2ALOGPS
pKa (Strongest Acidic)18.59Chemaxon
pKa (Strongest Basic)-3.8Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area107.05 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity76.94 m3·mol-1Chemaxon
Polarizability33.95 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-0019000000-7c4b7a3290efe4974657
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-03dj-0194000000-94ddb5075a3d81e915fa
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0aos-9162000000-f878643e8b80c093a1d8
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-03yl-7891000000-cb6dc5327412cf20d879
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-9210000000-fc26e2eee12c3ec75e3f
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-03fu-9210000000-0d1d4a84badd5819089f
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at August 18, 2020 15:20 / Updated at May 14, 2021 01:07