Benzyl nicotinate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Benzyl nicotinate is a rubefacient and vasodilator used in combination with analgesics in topical preparations.

Generic Name
Benzyl nicotinate
DrugBank Accession Number
DB15764
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 213.236
Monoisotopic: 213.078978598
Chemical Formula
C13H11NO2
Synonyms
  • Benzyl nicotinate
  • Nicotinic acid benzyl ester
  • Phenylmethyl 3-pyridinecarboxylate

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Products2
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AMMELTZ YOKO YOKOBenzyl nicotinate (10 mg/100ml) + Chlorpheniramine maleate (100 mg/100ml) + Glycol salicylate (2.5 g/100ml) + Levomenthol (3 g/100ml) + Nonivamide (12 mg/100ml)LiquidTopicalKOBAYASHI Healthcare (Malaysia) Sdn. Bhd.2020-09-08Not applicableMalaysia flag
HOTFİX 100 MG/G + 10 MG/G KREM , 50 GRAMBenzyl nicotinate (10 mg/g) + Etofenamate (100 mg/g)CreamTopicalKARFARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
NEW AMMELTZ YOKO YOKOBenzyl nicotinate (10 mg) + Glycol salicylate (2500 mg) + Levomenthol (3000 mg) + Nonivamide (12 mg)LiquidTopicalKOBAYASHI Healthcare (Malaysia) Sdn. Bhd.2020-09-08Not applicableMalaysia flag
NEW AMMELTZ YOKO YOKO PLUS MASSAGE TOPICAL LIQUIDBenzyl nicotinate (0.01 %) + Glycol salicylate (2.5 %) + Levomenthol (3 %) + Nonivamide (0.012 %)LiquidTopicalKOBAYASHI Healthcare (Malaysia) Sdn. Bhd.2020-09-08Not applicableMalaysia flag
RESTAFEN PLUS 5G /0,5G KREMBenzyl nicotinate (10 mg/g) + Etofenamate (100 mg/g)CreamTopicalVEM İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
THER-MERAM KREM ,50 GBenzyl nicotinate (10 mg/g) + Etofenamate (100 mg/g)CreamTopicalPHARMACTİVE İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
THERMO EFAMAT %10+%1 KREM, 50 GBenzyl nicotinate (1 %) + Etofenamate (10 %)CreamTopicalDeva Holding A.S.2020-08-14Not applicableTurkey flag
THERMO ETOX 50 G KREMBenzyl nicotinate (10 mg/g) + Etofenamate (100 mg/g)CreamTopicalTRİOZER İLAÇ KİM. KOZMETİK SAĞ. HİZM. SAN. VE TİC. LTD. ŞTİ.2020-08-14Not applicableTurkey flag
THERMO RHEUMON 100 MG/G + 10 MG/G KREM, 50 GBenzyl nicotinate (10 mg/g) + Etofenamate (100 mg/g)CreamTopicalMEDA PHARMA İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-14Not applicableTurkey flag
THERMO-DOLINE %10 + %1 KREM, 50 GBenzyl nicotinate (1 %) + Etofenamate (10 %)CreamTopicalTRIPHARMA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
S497LCF9C9
CAS number
94-44-0
InChI Key
KVYGGMBOZFWZBQ-UHFFFAOYSA-N
InChI
InChI=1S/C13H11NO2/c15-13(12-7-4-8-14-9-12)16-10-11-5-2-1-3-6-11/h1-9H,10H2
IUPAC Name
benzyl pyridine-3-carboxylate
SMILES
O=C(OCC1=CC=CC=C1)C1=CC=CN=C1

References

General References
  1. TITCK Product Information: THERMOFLEX (benzyl nicotinate and etofenamate) topical cream [Link]
KEGG Compound
C12865
ChemSpider
6923
RxNav
31767
ChEBI
31268
ChEMBL
CHEMBL209744
ZINC
ZINC000000391816
PDBe Ligand
0OM
PDB Entries
4eh5

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidTopical
EmulsionTopical
CreamTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.04 mg/mLALOGPS
logP2.4ALOGPS
logP2.48ChemAxon
logS-2ALOGPS
pKa (Strongest Basic)3.24ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area39.19 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity60.54 m3·mol-1ChemAxon
Polarizability22.39 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on August 19, 2020 22:48 / Updated on May 14, 2021 01:07