Algestone acetophenide
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Algestone acetophenide is a progestin indicated in combination with an estrogen as an injectable contraceptive.
- Generic Name
- Algestone acetophenide
- DrugBank Accession Number
- DB15775
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 448.603
Monoisotopic: 448.261359639 - Chemical Formula
- C29H36O4
- Synonyms
- Algeston acetofenid
- Algestone acetophenide
- Alphasone acetophenide
- Dihydroxyprogesterone acetophenide
- External IDs
- SO-15101
- SQ 15,101
- SQ 15101
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab Algestone acetophenide may decrease the anticoagulant activities of Abciximab. Acenocoumarol Algestone acetophenide may decrease the anticoagulant activities of Acenocoumarol. Alteplase Algestone acetophenide may decrease the anticoagulant activities of Alteplase. Ancrod Algestone acetophenide may decrease the anticoagulant activities of Ancrod. Anistreplase Algestone acetophenide may decrease the anticoagulant activities of Anistreplase. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Bovitrol / Droxone / Neolutin
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image SYNOVULAR SUAVE INYECTABLE Algestone acetophenide (90 mg) + Estradiol dienanthate (6 mg) Solution Intramuscular LABORATORIO FRANCO COLOMBIANO - LAFRANCOL S.A.S. 2008-07-04 Not applicable Colombia
Categories
- Drug Categories
- Adrenal Cortex Hormones
- Algestone
- Anti-Inflammatory Agents
- Contraceptive Agents, Female
- Contraceptive Agents, Hormonal
- Fused-Ring Compounds
- Hormonal Contraceptives for Systemic Use
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Pregnanes
- Pregnenediones
- Pregnenes
- Progesterone and Derivatives
- Progestins
- Reproductive Control Agents
- Steroids
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- OL7KC2O3OT
- CAS number
- 24356-94-3
- InChI Key
- AHBKIEXBQNRDNL-FVCOMRFXSA-N
- InChI
- InChI=1S/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28-,29-/m1/s1
- IUPAC Name
- (1R,2S,4R,6R,8S,9S,12S,13R)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-17-en-16-one
- SMILES
- [H][C@@]12C[C@H]3O[C@](C)(O[C@@]3(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C)C1=CC=CC=C1
References
- General References
- Ivademecum: SYNOVULAR (algestone acetophenide and estradiol dienanthate) injection [Link]
- External Links
- ChemSpider
- 4447595
- ChEBI
- 49327
- ChEMBL
- CHEMBL3989742
- ZINC
- ZINC000004172334
- Wikipedia
- Algestone_acetophenide
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intramuscular - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000357 mg/mL ALOGPS logP 5.2 ALOGPS logP 5.74 Chemaxon logS -6.1 ALOGPS pKa (Strongest Acidic) 17.63 Chemaxon pKa (Strongest Basic) -4.1 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 52.6 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 127.37 m3·mol-1 Chemaxon Polarizability 50.33 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-001j-0103900000-6ccd6819693d03e14ca0 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0002-0001900000-1a2a907f50b9283cd507 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-03yj-0796700000-62aea131db1dd603da5c Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-002b-0401900000-0a2d89dbcaaf859c7b18 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-002b-1203900000-18f9e23040daeab52238 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0zfr-0922100000-e9d6af723fb9028eda98 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 224.1990238 predictedDarkChem Lite v0.1.0 [M+H]+ 224.1848238 predictedDarkChem Lite v0.1.0 [M+Na]+ 224.3653238 predictedDarkChem Lite v0.1.0
Drug created at August 21, 2020 14:25 / Updated at May 14, 2021 01:07