This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Algestone acetophenide is a progestin indicated in combination with an estrogen as an injectable contraceptive.

Generic Name
Algestone acetophenide
DrugBank Accession Number
DB15775
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 448.603
Monoisotopic: 448.261359639
Chemical Formula
C29H36O4
Synonyms
  • Algeston acetofenid
  • Algestone acetophenide
  • Alphasone acetophenide
  • Dihydroxyprogesterone acetophenide
External IDs
  • SO-15101
  • SQ 15,101
  • SQ 15101

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Algestone acetophenide is combined with Abciximab.
AcenocoumarolThe risk or severity of adverse effects can be increased when Algestone acetophenide is combined with Acenocoumarol.
AcetaminophenThe metabolism of Algestone acetophenide can be increased when combined with Acetaminophen.
AcetazolamideThe metabolism of Algestone acetophenide can be increased when combined with Acetazolamide.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Algestone acetophenide.
AlpelisibThe metabolism of Algestone acetophenide can be increased when combined with Alpelisib.
AlteplaseThe risk or severity of adverse effects can be increased when Algestone acetophenide is combined with Alteplase.
AminoglutethimideThe metabolism of Algestone acetophenide can be increased when combined with Aminoglutethimide.
AmobarbitalThe metabolism of Algestone acetophenide can be increased when combined with Amobarbital.
AmoxicillinThe therapeutic efficacy of Algestone acetophenide can be decreased when used in combination with Amoxicillin.
Interactions
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Food Interactions
Not Available

Products

Products2
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International/Other Brands
Bovitrol / Droxone / Neolutin
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
SYNOVULAR SUAVE INYECTABLEAlgestone acetophenide (90 mg) + Estradiol dienanthate (6 mg)SolutionIntramuscularLABORATORIO FRANCO COLOMBIANO - LAFRANCOL S.A.S.2008-07-04Not applicableColombia flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
OL7KC2O3OT
CAS number
24356-94-3
InChI Key
AHBKIEXBQNRDNL-FVCOMRFXSA-N
InChI
InChI=1S/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28-,29-/m1/s1
IUPAC Name
(1R,2S,4R,6R,8S,9S,12S,13R)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-17-en-16-one
SMILES
[H][C@@]12C[C@H]3O[C@](C)(O[C@@]3(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C)C1=CC=CC=C1

References

General References
  1. Ivademecum: SYNOVULAR (algestone acetophenide and estradiol dienanthate) injection [Link]
ChemSpider
4447595
ChEBI
49327
ChEMBL
CHEMBL3989742
ZINC
ZINC000004172334
Wikipedia
Algestone_acetophenide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000357 mg/mLALOGPS
logP5.2ALOGPS
logP5.74ChemAxon
logS-6.1ALOGPS
pKa (Strongest Acidic)17.63ChemAxon
pKa (Strongest Basic)-4.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area52.6 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity127.37 m3·mol-1ChemAxon
Polarizability50.33 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at August 21, 2020 14:25 / Updated at May 14, 2021 01:07