Platelet Lysate
Identification
- Name
- Platelet Lysate
- Accession Number
- DB15869
- Description
Platelet lysate is an acellular compound composed of platelet proteins while also being void of cellular debris, thus making the lysate rich with growth factors.1 It is extracted through lysis of the plasma membrane of platelets. Because white cell antigens are low in prepared lysate, there is a minimized likelihood of immune responses.
- Type
- Biotech
- Groups
- Investigational
- Biologic Classification
- Protein Based Therapies
Blood factors - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- Not Available
- External IDs
- Platelet Lysate
Pharmacology
- Indication
- Not Available
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
Platelet lysate plays a role in regeneration through the growth factors it contains, resulting in an increase in cell proliferation and angiogenesis. Nebulized platelet lysate can be administered to the lungs and has applications in treatment of acute lung injuries, chronic obstructive pulmonary disease (COPD), and asthma. Because of the aforementioned diseases that the plasma lysate can treat and its ability to relegate severe inflammatory processes of the respiratory tract, it is currently also being investigated against COVID-19 infection-related acute respiratory syndrome (ARDS).
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
References
- General References
- Jeyaraman M, Ranjan R, Kumar R, Arora A, Chaudhary D, Ajay SS, Jain R: Cellular Therapy: Shafts of Light Emerging for COVID-19. Stem Cell Investig. 2020 Jun 30;7:11. doi: 10.21037/sci-2020-022. eCollection 2020. [PubMed:32695804]
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Knee Joint Osteoarthrosis 1 1, 2 Completed Treatment Acne Scarring 1 1, 2 Completed Treatment Critical Limb Ischemia (CLI) 1 1, 2 Recruiting Treatment Diabetic Foot Ulcers (DFU) 1 1, 2 Recruiting Treatment Peripheral Arterial Disease (PAD) 1 1, 2 Recruiting Treatment Persistent Corneal Epithelial Defects 1 1, 2 Unknown Status Treatment Androgenetic Alopecia 2 1, 2 Unknown Status Treatment Lateral Epicondylitis (Tennis Elbow) 1 Not Available Recruiting Treatment Coronavirus Disease 2019 (COVID‑19) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created on September 21, 2020 10:33 / Updated on September 22, 2020 07:00