Copper oxodotreotide Cu-64 is a Cu labeled somatostatin analog used in positron emission tomography to detect certain types of neuroendocrine tumors. Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over 68Ga-labeled somatostatin analogs for positron emission tomography (PET).
- Mechanism
- Curator reviewed · 2 references
The main target of the positron-emitting Copper Cu 64 dotatate is somatostatin receptor type 2 (SSTR2). SSTR2 is frequently overexpressed in malignant neuroendocrine cells; therefore, accumulation of the radionuclide at the site permits PET imaging to occur.
- Primary indication
- Copper Cu 64 Dotatate is a radiopharmaceutical used with positron emission tomography(PET) to locate somatostatin receptor-positive neuroendocrine tumors.Curator reviewed · 1 structured indication
- Formula / weight
- C65H88CuN14O19S2 · 1497.55 g/mol (avg)
- First approval
- United States, 2020
- Also known as
- 64Cu-dotatate · Copper 64-DOTA-tate · Copper Cu-64 dotatate · Copper dotatate Cu-64
Resolves to
IJRLLVFQGCCPPI-NVGRTJHCSA-LSMILES[64Cu++].C[C@@H](O)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)CN2CCN(CC(O)=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC2)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@H](CC2=CNC3=C2C=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(O)=OWhat you can answer from here — as of June 04, 2026
Which drugs share a target with Copper oxodotreotide Cu-64, and which of those have an active Phase 3 trial?
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