Pirenoxine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Pirenoxine is a medication indicated to treat cataracts.

Generic Name
Pirenoxine
DrugBank Accession Number
DB15945
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 308.249
Monoisotopic: 308.043321366
Chemical Formula
C16H8N2O5
Synonyms
  • Pirenoxina
  • Pirenoxine
  • Pirenoxinum
External IDs
  • 213-872-4

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Pirenoxine sodium95JU7URF6451410-30-1HDQXPMXHXZNPKE-UHFFFAOYSA-M

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
27L0EP6IZK
CAS number
1043-21-6
InChI Key
OKPNYGAWTYOBFZ-UHFFFAOYSA-N
InChI
InChI=1S/C16H8N2O5/c19-9-5-8(16(21)22)18-14-10(20)6-12-15(13(9)14)17-7-3-1-2-4-11(7)23-12/h1-6H,(H,18,19)(H,21,22)
IUPAC Name
4-hydroxy-12-oxo-12H-10-oxa-1,5-diazatetraphene-2-carboxylic acid
SMILES
OC(=O)C1=NC2=C(C(O)=C1)C1=NC3=CC=CC=C3OC1=CC2=O

References

General References
  1. AIFA: Clarvisan PVA (Pirenoxine) Ophthalmic Solution [Link]
ChemSpider
4680
RxNav
228080
ChEBI
32013
ChEMBL
CHEMBL1372341
ZINC
ZINC000011616009
Wikipedia
Pirenoxine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidOphthalmic0.05 mg/1ml
Solution / dropsOphthalmic
Powder, for solutionOphthalmic
Solution / drops; tablet, for solutionOphthalmic0.75 mg/1tablet
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.129 mg/mLALOGPS
logP1.82ALOGPS
logP-0.12ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)0.79ChemAxon
pKa (Strongest Basic)6.02ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area109.08 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity81.43 m3·mol-1ChemAxon
Polarizability29.5 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on November 26, 2020 14:21 / Updated on May 07, 2021 21:09