NAV

Histamine glutarimide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Histamine glutarimide
DrugBank Accession Number
DB16016
Background

Histamine glutarimide is under investigation in clinical trial NCT03450434 (XC8 in the Treatment of Patients With Bronchial Asthma).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 207.233
Monoisotopic: 207.100776671
Chemical Formula
C10H13N3O2
Synonyms
Not Available
External IDs
  • XC 8
  • XC-8
  • XC8
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
VOM9DP10M3
CAS number
1464897-15-1
InChI Key
DYKZYSKWOHKZMF-UHFFFAOYSA-N
InChI
InChI=1S/C10H13N3O2/c14-9-2-1-3-10(15)13(9)5-4-8-6-11-7-12-8/h6-7H,1-5H2,(H,11,12)
IUPAC Name
1-[2-(1H-imidazol-5-yl)ethyl]piperidine-2,6-dione
SMILES
O=C1CCCC(=O)N1CCC1=CN=CN1

References

General References
  1. Renner A, Romanova J, Ferko B, Schmutz H, Nebolsin V, Muller M, Badorrek P, Marth K, Pohl W: Safety, pharmacokinetics and pharmacodynamics of a novel anti-asthmatic drug, XC8, in healthy probands. Pulm Pharmacol Ther. 2019 Dec;59:101852. doi: 10.1016/j.pupt.2019.101852. Epub 2019 Oct 6. [Article]
ChemSpider
48673501

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentBronchial Asthma1
2CompletedTreatmentBronchial Asthma / Eosinophilic Asthma1
2, 3CompletedTreatmentAcute Respiratory Infections (ARIs) / Flu caused by Influenza1
1CompletedBasic ScienceAsthma1
1CompletedTreatmentAsthma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility8.4 mg/mLALOGPS
logP0.12ALOGPS
logP-0.74Chemaxon
logS-1.4ALOGPS
pKa (Strongest Acidic)12.94Chemaxon
pKa (Strongest Basic)6.75Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area66.06 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity54.09 m3·mol-1Chemaxon
Polarizability21.34 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-1290000000-6f7f67d893ce8aea3dd5
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-0790000000-4cda9fb400bf73c717df
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-000j-9800000000-abbe7612ed2fc1226430
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0f6t-9410000000-ea2f395795d91dd5cb22
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-7900000000-243c811f8a51914cbb3e
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001j-9400000000-b835022588080515a41e
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at December 11, 2020 23:39 / Updated at December 12, 2020 04:16