GZ-389988

DB16056InvestigationalSmall molecule

GZ-389988 is under investigation in clinical trial NCT02845271 (Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful...

Mechanism: Pharmacologically active on High affinity nerve growth factor receptor
Curator reviewed
Formula / weight: C₂₆H₂₆N₆O₃ · 470.533 g/mol (avg)
Code names: GZ-389988

Resolves to

Compound

UNIIXX8E5WP7FSCAS1788906-96-6ChEMBLCHEMBL3673452

Structure

InChIKeyHVRWZFQFSQUILC-UHFFFAOYSA-NSMILESCOC1=CC=C(COC2=CC=C(CN3C(N)=NC4=C3N=CC(=C4)C3=CN(C)N=C3)C=C2OC)C=C1

Targets

P04629NTRK1Q16620NTRK2Q16288NTRK3

What you can answer from here — as of June 15, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with GZ-389988, and which of those have an active Phase 3 trial?

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