OBI-3424

DB16057InvestigationalSmall molecule

OBI-3424 is under investigation in clinical trial NCT04315324 (Study to Test Akr1c3-activated Prodrug OBI-3424 (OBI-3424) in Patients With Relapsed/refractory T-cell Acute Lymphoblastic Leukemia (T-ALL)).

Mechanism: Pharmacologically active on Aldo-keto reductase family 1 member C3
Curator reviewed
Formula / weight: C₂₁H₂₅N₄O₆P · 460.427 g/mol (avg)
Also known as: 3-(5-((1R)-1-(Bis(aziridin-1-yl(phosphoryloxy)ethyl)-2-nitrophenoxy)-N,N-dimethylbenzamide · 3-[5-[(1R)-1-[bis(aziridin-1-yl(phosphoryloxy]ethyl]-2-nitrophenoxy]-N,N-dimethylbenzamide · Phosphinic acid, P,P-bis(1-aziridinyl)-, (1R)-1-(3-(3-((dimethylamino)carbonyl)phenoxy)-4-nitrophenyl)ethyl ester
Code names: OBI-3424 · TH-3424

Resolves to

Compound

UNIIX6SH5T8H76CAS2097713-68-1ChEMBLCHEMBL4297474

Structure

InChIKeyNWGZZGNICQFUHV-OAHLLOKOSA-NSMILESC[C@@H](OP(=O)(N1CC1)N1CC1)C1=CC(OC2=CC(=CC=C2)C(=O)N(C)C)=C(C=C1)[N+]([O-])=O

Targets

P42330AKR1C3

What you can answer from here — as of July 08, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with OBI-3424, and which of those have an active Phase 3 trial?

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