NSI-189

DB16230InvestigationalSmall molecule

NSI-189 is under investigation in clinical trial NCT02695472 (Study of NSI-189 for Major Depressive Disorder).

Chemical structure of NSI-189
Formula / weight
C22H30N4O · 366.509 g/mol (avg)
Code names
NSI-189

Resolves to

Compound
UNIIYVE9U408ZLCAS1270138-40-3ChEMBLCHEMBL4302505
Structure
InChIKeyDYTOQURYRYYNOR-UHFFFAOYSA-NSMILESCC(C)CCNC1=NC=CC=C1C(=O)N1CCN(CC2=CC=CC=C2)CC1

What you can answer from here — as of September 23, 2026

3Clinical trialsPhase, status and sponsor resolved per trial
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Which companies are running trials of NSI-189, in which indications and phases, and which of those programs are still active?

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