Apinocaltamide

DB16241InvestigationalSmall molecule

Apinocaltamide is under investigation in clinical trial NCT03239691 (A Study to Evaluate the Effect of ACT-709478 in Photosensitive Epilepsy Patients).

Mechanism: Pharmacologically active on Voltage-dependent T-type calcium channel
Curator reviewed
Formula / weight: C₂₂H₁₈F₃N₅O · 425.415 g/mol (avg)
Also known as: Benzeneacetamide, N-[1-[(5-cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]- · N-(1-((5-CYANOPYRIDIN-2-YL)METHYL)-1H-PYRAZOL-3-YL)-2-(4-(1-(TRIFLUOROMETHYL)CYCLOPROPYL)-PHENYL)ACETAMIDE · N-[1-(5-Cyano-pyridin-2-ylmethyl)-1H-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl-phenyl]-acetamide · N-[1-[(5-Cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]benzeneacetamide · N-{1-[(5-cyanopyridin-2-yl)methyl]-1H-pyrazol-3-yl}-2- {4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamide
Code names: ACT-709478

Resolves to

Compound

UNII3Z7U1U8Z9ECAS1838651-58-3ChEMBLCHEMBL4217292ChEBI194340

Structure

InChIKeyLSYANGLAZUZYFX-UHFFFAOYSA-NSMILESFC(F)(F)C1(CC1)C1=CC=C(CC(=O)NC2=NN(CC3=NC=C(C=C3)C#N)C=C2)C=C1

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which companies are running trials of Apinocaltamide, in which indications and phases, and which of those programs are still active?

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