Dovramilast

DB16242InvestigationalSmall molecule

Dovramilast is under investigation in clinical trial NCT01300208 (To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus...

Mechanism: Pharmacologically active on Phosphodiesterase 4
Curator reviewed
Formula / weight: C₂₄H₂₈N₂O₆S · 472.56 g/mol (avg)
Also known as: Cyclopropanecarboxamide, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-3-oxo-1H-isoindol-4-yl]- · N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2- (methanesulfonyl)ethyl]-3-oxo-2,3-dihydro-1H-isoindol- 4-yl}cyclopropanecarboxamide · N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}cyclopropanecarboxamide
Code names: CC-11050

Resolves to

Compound

UNII1Z08G7438ACAS340019-69-4ChEMBLCHEMBL4297460

Structure

InChIKeyQDZOBXFRIVOQBR-LJQANCHMSA-NSMILESCCOC1=C(OC)C=CC(=C1)[C@@H](CS(C)(=O)=O)N1CC2=CC=CC(NC(=O)C3CC3)=C2C1=O

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which companies are running trials of Dovramilast, in which indications and phases, and which of those programs are still active?

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