F-652

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
F-652
Accession Number
DB16366
Description

F-652 is a recombinant IL-22-Fc fusion protein manufactured in Chinese hamster ovary cells that is composed of 2 human interleukin 22 (IL-22) molecules linked to an immunoglobulin constant region (IgG2-Fc).1,2 It is being developed by Evive Biotech (previously known as Generon BioMed Inc).3

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Fusion proteins
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • IL-22 fusion protein
External IDs
  • F-652

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action

F-652 incorporates human interleukin 22’s (IL-22) natural epithelial cell growth-promoting activity as IL-22 plays critical roles in promoting tissue repair and suppressing bacterial infection.1,2 F-652 is currently being investigated against acute graft vs host disease, acute alcoholic hepatitis, inflammatory diseases, organ injuries, eventual fatal organ failures, and COVID-19.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Tang KY, Lickliter J, Huang ZH, Xian ZS, Chen HY, Huang C, Xiao C, Wang YP, Tan Y, Xu LF, Huang YL, Yan XQ: Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects. Cell Mol Immunol. 2019 May;16(5):473-482. doi: 10.1038/s41423-018-0029-8. Epub 2018 Apr 18. [PubMed:29670279]
  2. Evive Biotech: F-652 [Link]
  3. BioSpectrum: Evive Biotech unveiled as the new corporate brand for Generon Biomed [Link]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19)1
1, 2Active Not RecruitingTreatmentAcute Graft vs Host Disease1
1, 2CompletedTreatmentAlcoholic Hepatitis (AH)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on December 18, 2020 08:25 / Updated on December 19, 2020 20:42